CRISPR/Cas9-mediated mutagenesis of the mediator complex subunits MED5a and MED5b genes impaired secondary metabolite accumulation in hop (Humulus …

P Awasthi, AK Mishra, T Kocábek, VS Nath… - Plant Physiology and …, 2023 - Elsevier
Hop (Humulus lupulus L.) is an important commercial crop known for the biosynthesis of
valuable specialized secondary metabolites in glandular trichomes (lupulin glands), which …

COP9 signalosome subunit 5A affects phenylpropanoid metabolism, trichome formation and transcription of key genes of a regulatory tri-protein complex in …

S Wei, X Li, MY Gruber, BA Feyissa, L Amyot… - BMC plant biology, 2018 - Springer
Background Trichomes and phenylpropanoid-derived phenolics are structural and chemical
protection against many adverse conditions. Their production is regulated by a network that …

CRISPR/Cas9 genome‐editing applied to MdPGT1 in apple results in reduced foliar phloridzin without impacting plant growth

S Miranda, S Piazza, F Nuzzo, M Li, J Lagrèze… - The Plant …, 2023 - Wiley Online Library
Phloridzin is the most abundant polyphenolic compound in apple (Malus× domestica
Borkh.), which results from the action of a key phloretin‐specific UDP‐2′‐O …

Dissection of Dynamic Transcriptome Landscape of Leaf, Bract, and Lupulin Gland in Hop (Humulus lupulus L.)

AK Mishra, T Kocábek, V Sukumari Nath… - International journal of …, 2019 - mdpi.com
The hop plant (Humulus lupulus L.) produces several valuable secondary metabolites, such
as prenylflavonoid, bitter acids, and essential oils. These compounds are biosynthesized in …

Genome-Wide Survey of the RWP-RK Gene Family in Cassava (Manihot esculenta Crantz) and Functional Analysis

C Lin, X Guo, X Yu, S Li, W Li, X Yu, F An… - International Journal of …, 2023 - mdpi.com
The plant-specific RWP-RK transcription factor family plays a central role in the regulation of
nitrogen response and gametophyte development. However, little information is available …

Comparative transcriptomics of Pinus massoniana organs provides insights on terpene biosynthesis regulation

Q Bai - Physiologia Plantarum, 2022 - Wiley Online Library
Terpenoids are the most important natural products collected from conifer species. However,
the molecular mechanisms and core factors underlying terpenoid biosynthesis in Pinus …

Establishment of CRISPR/Cas9 mediated targeted mutagenesis in hop (Humulus lupulus)

P Awasthi, T Kocábek, AK Mishra, VS Nath… - Plant Physiology and …, 2021 - Elsevier
The CRISPR/Cas9-based targeted genome editing has emerged as a versatile technique,
widely employed in plant genome engineering, both to decipher gene function and as an …

The multifaceted roles of R2R3 transcription factor Hl MYB7 in the regulation of flavonoid and bitter acids pathways, development and biotic stress in hop (Humulus …

AK Mishra, T Kocábek, VS Nath, A Khan, J Matoušek… - bioRxiv, 2022 - biorxiv.org
Hop (Humulus lupulus) biosynthesizes the highly economically valuable secondary
metabolites, which include flavonoids, bitter acids, polyphenols and essential oils. These …

CRISPR/Cas9-mediated targeted mutagenesis of bZIP2 in Salvia miltiorrhiza leads to promoted phenolic acid biosynthesis

M Shi, Z Du, Q Hua, G Kai - Industrial Crops and Products, 2021 - Elsevier
Phenolic acids comprise the major bioactive compounds in Salvia miltiorrhiza, which can be
increased by abscisic acid (ABA) elicitation. However, the underlying regulation mechanism …

Cloning and molecular analysis of HlbZip1 and HlbZip2 transcription factors putatively involved in the regulation of the lupulin metabolome in hop (Humulus lupulus L …

J Matousek, T Kocabek, J Patzak, J Stehlik… - Journal of agricultural …, 2010 - ACS Publications
Hop (Humulus lupulus L.), the essential source of beer flavor is of interest from a medicinal
perspective in view of its high content in health-beneficial terpenophenolics including …