Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

Aging populations face diminishing quality of life due to increased disease and morbidity.
These challenges call for longevity research to focus on understanding the pathways …

We developed a new statistical framework to find genetic variants associated with extreme
longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

The enormous variation in human lifespan is in part due to a myriad of sequence variants,
only a few of which have been revealed to date. Since many life-shortening events are …

Human longevity and healthy aging show moderate heritability (20%–50%). We conducted
a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for …

Human lifespan variation is mainly determined by environmental factors, whereas the
genetic contribution is 25–30% and expected to be polygenic. Two complementary fields go …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …