Background Sedentary lifestyle is a major risk factor for noncommunicable diseases such as
cardiovascular diseases, cancer and diabetes. It has been estimated that approximately 3.2 …

The evidence that higher levels of physical activity and/or lower levels of physical inactivity
are associated with beneficial health-related outcomes stems mainly from observational …

Objective To determine the comparative effectiveness of exercise versus drug interventions
on mortality outcomes. Design Metaepidemiological study. Eligibility criteria Meta-analyses …

Purpose of review The health benefits of physical activity and exercise are clear; virtually
everyone can benefit from becoming more physically active. Most international guidelines …

The primary purpose of this narrative review was to evaluate the current literature and to
provide further insight into the role physical inactivity plays in the development of chronic …

Background The objective of this study was to derive evidence-based physical activity
guidelines for the general Dutch population. Methods Two systematic reviews were …

Background Although previous studies have found physical activity to be associated with
lower mortality, the dose–response relationship remains unclear. In this systematic review …

Background The dose–response relation between physical activity and all-cause mortality is
not well defined at present. We conducted a systematic review and meta-analysis to …

Purpose. Conduct a systematic umbrella review to evaluate the relationship of physical
activity (PA) with all-cause mortality, cardiovascular mortality, and incident cardiovascular …

In a meta-analysis we investigated the effect of physical activity with different intensity
categories on all-cause mortality. Many studies have reported positive effects of regular …