[PDF][PDF] Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination
Background Development of an effective vaccine against the pathogenic blood-stage
infection of human malaria has proved challenging, and no candidate vaccine has affected …
infection of human malaria has proved challenging, and no candidate vaccine has affected …
[HTML][HTML] Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions
RO Payne, SE Silk, SC Elias, K Miura, A Diouf… - JCI insight, 2017 - ncbi.nlm.nih.gov
The development of a highly effective vaccine remains a key strategic goal to aid the control
and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte …
and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte …
Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells
J Jin, RD Tarrant, EJ Bolam, P Angell-Manning… - npj Vaccines, 2018 - nature.com
Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is a leading asexual
blood-stage vaccine candidate for malaria. In preparation for clinical trials, a full-length …
blood-stage vaccine candidate for malaria. In preparation for clinical trials, a full-length …
[HTML][HTML] Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5. 1/AS01B malaria vaccine
Modifications to vaccine delivery that increase serum antibody longevity are of great interest
for maximizing efficacy. We have previously shown that a delayed fractional (DFx) dosing …
for maximizing efficacy. We have previously shown that a delayed fractional (DFx) dosing …
Bacterially expressed full-length recombinant Plasmodium falciparum RH5 protein binds erythrocytes and elicits potent strain-transcending parasite-neutralizing …
Plasmodium falciparum reticulocyte binding-like homologous protein 5 (PfRH5) is an
essential merozoite ligand that binds with its erythrocyte receptor, basigin. PfRH5 is an …
essential merozoite ligand that binds with its erythrocyte receptor, basigin. PfRH5 is an …
Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination
TJ Suscovich, JK Fallon, J Das, AR Demas… - Science translational …, 2020 - science.org
Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …
immunology analyses and controlled human infection models to define the protective …
Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy?
CJA Duncan, AVS Hill, RD Ellis - Human vaccines & …, 2012 - Taylor & Francis
An effective vaccine against P. falciparum malaria remains a global health priority. Blood-
stage vaccines are an important component of this effort, with some indications of recent …
stage vaccines are an important component of this effort, with some indications of recent …
Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From …
TM Tran, A Ongoiba, J Coursen… - The Journal of …, 2014 - academic.oup.com
Background. Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) is a
blood-stage parasite protein essential for host erythrocyte invasion. PfRH5-specific …
blood-stage parasite protein essential for host erythrocyte invasion. PfRH5-specific …
A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS, S malaria vaccine
Abstract Background The RTS, S malaria vaccine is currently undergoing phase 3 trials.
High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have …
High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have …
[PDF][PDF] The RTS, S vaccine—a chance to regain the upper hand against malaria?
Malaria is estimated by the World Health Organization (WHO) to have killed 627,000
individuals worldwide in 2020, with nearly 80% of deaths in African children younger than …
individuals worldwide in 2020, with nearly 80% of deaths in African children younger than …