Immunodominant regions for T helper-cell sensitization on the human nicotinic receptor alpha subunit in myasthenia gravis.
MP Protti, AA Manfredi, C Straub… - Proceedings of the …, 1990 - National Acad Sciences
In myasthenia gravis an autoimmune response against the nicotinic acetylcholine receptor
(AChR) occurs. The alpha subunit of the AChR contains both the epitope (s) that dominates …
(AChR) occurs. The alpha subunit of the AChR contains both the epitope (s) that dominates …
Amphipathic segment of the nicotinic receptor alpha subunit contains epitopes recognized by T lymphocytes in myasthenia gravis.
R Hohlfeld, KV Toyka, LL Miner… - The Journal of …, 1988 - Am Soc Clin Investig
Autoimmune helper T lymphocytes were selected from the blood of two myasthenic patients
of different HLA-DR type, using acetylcholine receptor (AChR) from Torpedo californica …
of different HLA-DR type, using acetylcholine receptor (AChR) from Torpedo californica …
T-helper epitopes on human nicotinic acetylcholine receptor in myasthenia gravis.
The synthesis of AChR antibodies requires intervention of AChR-specific Th cells. Because
of the paucity of anti-AChR Th cells in the blood of myasthenia gravis (MG) patients, direct …
of the paucity of anti-AChR Th cells in the blood of myasthenia gravis (MG) patients, direct …
Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor alpha subunit.
R Hohlfeld, KV Toyka, SJ Tzartos… - Proceedings of the …, 1987 - National Acad Sciences
Myasthenia gravis is a human disease caused by an autoimmune response against the
nicotinic acetylcholine receptor (AcChoR). Since the molecular structure of AcChoR is well …
nicotinic acetylcholine receptor (AcChoR). Since the molecular structure of AcChoR is well …
T cells from normal and myasthenic individuals recognize the human acetylcholine receptor: heterogeneity of antigenic sites on the α‐subunit
A Melms, G Malcherek, U Gern… - Annals of Neurology …, 1992 - Wiley Online Library
The α‐subunit of the nicotinic acetylcholine receptor is the major target of the autoimmune
response in myasthenia gravis. We investigated the proligerative response of T cells from …
response in myasthenia gravis. We investigated the proligerative response of T cells from …
Autoimmune T lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine …
A Melms, S Chrestel, BC Schalke… - The Journal of …, 1989 - Am Soc Clin Investig
Oligoclonal and cloned T lines from peripheral blood or thymuses of patients with
myasthenia gravis (MG) were selected for reactivity against nicotinic acetylcholine receptors …
myasthenia gravis (MG) were selected for reactivity against nicotinic acetylcholine receptors …
[引用][C] Acetylcholine Receptor: Molecular Dissection and Monoclonal Antibodies in the Study of Experimental my Asthenia
S Fuchs, D Bartfeld, D Mochly‐Rosen… - Annals of the New …, 1981 - Wiley Online Library
The involvement of an autoimmune response (cellular and humoral) to the nicotinic
acetylcholine receptor (AChR) in myasthenia gravis (MG) is well established now. The …
acetylcholine receptor (AChR) in myasthenia gravis (MG) is well established now. The …
Human acetylcholine receptor presentation in myasthenia gravis. DR restriction of autoimmune T epitopes and binding of synthetic receptor sequences to DR …
Autoimmune Th cells in myasthenia gravis recognize several sequence regions of the
human muscle acetylcholine receptor (AChR). Most AChR Th epitopes are presented by …
human muscle acetylcholine receptor (AChR). Most AChR Th epitopes are presented by …
T cell epitopes in experimental autoimmune myasthenia gravis of the rat: strain‐specific epitopes and cross‐reaction between two distinct segments of the α chain of …
Y Zhang, T Barkas, M Juillerat… - European journal of …, 1988 - Wiley Online Library
T cell epitopes on the nicotinic acetylcholine receptor (AChR) of Torpedo californica were
analyzed using T cell lines isolated from Lewis, BN, and (Lewis x BN) F1 rats. All lines …
analyzed using T cell lines isolated from Lewis, BN, and (Lewis x BN) F1 rats. All lines …
Autoimmune T cell recognition of human acetylcholine receptor: the sites of T cell recognition in myasthenia gravis on the extracellular part of the α subunit
M Oshima, T Ashizawa, MS Pollack… - European journal of …, 1990 - Wiley Online Library
Autoimune T cell lines were prepared from peripheral blood lymphocytes of five myasthenia
gravis patients by passage in vitro with an equimolar mixture of 18 overlapping synthetic …
gravis patients by passage in vitro with an equimolar mixture of 18 overlapping synthetic …
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- myasthenia gravis acetylcholine receptor
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- acetylcholine receptor cell recognition
- acetylcholine receptor α subunit
- myasthenia gravis autoimmune t lymphocytes
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