Chronic myeloid leukemia (CML) is caused by a Bcr-Abl protein, which results from the
fusion of 5 region of the BCR gene fused to the second exon of the ABL gene. The resulting …

ABSTRACT Introduction Chronic Myeloid Leukemia (CML) is probably the most extensively
studied human malignancy. CML patients (90-95%) harbor the Philadelphia (Ph) …

Abstract 4831 Patient with CML harbor the chromosomal translocation t (9; 22) which
corresponds to fusion of the BCR and ABL genes at the DNA level. Traditionally, CML …

Background Philadelphia chromosome, a hallmark of chronic myeloid leukemia (CML),
plays a key role in disease pathogenesis. It reflects a balanced reciprocal translocation …

Diagnosis and monitoring of therapy in chronic myeloid leukemia (CML) depend on
cytogenetic, FISH, and PCR assays for detecting the fusion bcr-abl gene. However, the there …

Chronic Myeloid Leukemia (CML) is a clonal disorder originated by a pluripotent
hematopoietic stem cell, which presents the translocation t (9; 22)(q34; q11) in 90% of the …

Important advances in the understanding of the molecular basis of chronic myeloid leukemia
have resulted in the development of new therapies and changed the paradigm for managing …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm characterized by a
structural chromosomal aberration. The BCR-ABL tyrosine kinase produced by the t (9; …

Background: A specific chromosomal abnormality, the Philadelphia chromosome (Ph), is
present in 90-95% of patients with chronic myeloid leukemia (CML). This aberration results …

Chronic Myeloid Leukemia (CML) is a type of myeloproliferative neoplasms, specified by the
high number of granulocytes in the peripheral blood, and accounted for 15%-20% of all …