Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade
extracellular material that has been internalized by endocytosis and intracellular …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Lysosomes clear macromolecules, maintain nutrient and cholesterol homeostasis,
participate in tissue repair, and in many other cellular functions. To assume these tasks …

Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …

Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

The lysosomal membrane was thought for a long time to primarily act as a physical barrier
separating the luminal acidic milieu from the cytoplasmic environment. Meanwhile, it has …

Lysosomes are acidic cell compartments containing a large set of hydrolytic enzymes. These
lysosomal hydrolases degrade proteins, lipids, polysaccharides, and nucleic acids into their …

Lysosomes are specialized compartments for the degradation of endocytosed and
intracellular material and essential regulators of cellular homeostasis. The importance of …

Lysosomal storage disorders, of which more than 40 are known, are caused by the defective
activity of lysosomal proteins, which results in the intra-lysosomal accumulation of …