RGD-decorated PLGA nanoparticles improved effectiveness and safety of cisplatin for lung cancer therapy

B Yadav, M Chauhan, S Shekhar, A Kumar… - International Journal of …, 2023 - Elsevier
Upon extensive pharmaceutical and biomedical research to treat lung cancer indicates that
lung cancer remains one of the deadliest diseases and the leading cause of death in men …

Repurposing itraconazole loaded PLGA nanoparticles for improved antitumor efficacy in non-small cell lung cancers

NA Alhakamy, S Md - Pharmaceutics, 2019 - mdpi.com
Itraconazole (ITR) is a broad-spectrum antifungal drug, which has been shown to possess
some promising anticancer, anti-proliferative, and anti-angiogenic properties in some …

[HTML][HTML] Gefitinib loaded PLGA and chitosan coated PLGA nanoparticles with magnified cytotoxicity against A549 lung cancer cell lines

AS Alshetaili - Saudi journal of biological sciences, 2021 - Elsevier
In the current study, gefitinib loaded PLGA nanoparticles (GFT-PLGA-NPs) and chitosan
coated PLGA nanoparticles (GFT-CS-PLGA-NPs) were synthesized to investigate the role of …

Novel silibinin loaded chitosan-coated PLGA/PCL nanoparticles based inhalation formulations with improved cytotoxicity and bioavailability for lung cancer

M Raval, P Patel, V Airao, V Bhatt, N Sheth - Bionanoscience, 2021 - Springer
Silibinin is widely used as an anticancer agent. There are important matters of concern
regarding the drug pharmacokinetics related to the conventional formulation due to their low …

A novel combination for the treatment of small cell lung cancer: Active targeted irinotecan and stattic co-loaded PLGA nanoparticles

FB Arslan, K Öztürk, E Tavukçuoğlu, SC Öztürk… - International Journal of …, 2023 - Elsevier
Polymeric nanoparticles are widely used drug delivery systems for cancer treatment due to
their properties such as ease of passing through biological membranes, opportunity to …

Oral delivery of DMAB-modified docetaxel-loaded PLGA-TPGS nanoparticles for cancer chemotherapy

H Chen, Y Zheng, G Tian, Y Tian, X Zeng, G Liu… - Nanoscale Res …, 2011 - Springer
Three types of nanoparticle formulation from biodegradable PLGA-TPGS random copolymer
were developed in this research for oral administration of anticancer drugs, which include …

Targeted delivery of monoclonal antibody conjugated docetaxel loaded PLGA nanoparticles into EGFR overexpressed lung tumour cells

J Patel, J Amrutiya, P Bhatt, A Javia… - Journal of …, 2018 - Taylor & Francis
The aim of this study was to develop anti-EGFR antibody conjugated poly (lactide-co-
glycolide) nanoparticles (NPs) to target epidermal growth factor receptor, highly expressed …

Formulation, optimization, hemocompatibility and pharmacokinetic evaluation of PLGA nanoparticles containing paclitaxel

P Mittal, H Vardhan, G Ajmal, GV Bonde… - Drug development …, 2019 - Taylor & Francis
Abstract Objective: Paclitaxel (PTX)-loaded polymer (Poly (lactic-co-glycolic acid), PLGA)-
based nanoformulation was developed with the objective of formulating cremophor EL-free …

Co-administration of iRGD enhances tumor-targeted delivery and anti-tumor effects of paclitaxel-loaded PLGA nanoparticles for colorectal cancer treatment

Y Zhong, T Su, Q Shi, Y Feng, Z Tao… - International journal …, 2019 - Taylor & Francis
Background Nanoparticles exhibit great promise for improving the solubility and tissue-
specific distribution of chemotherapeutic agents; however, the passive and highly variable …

Chemodrug delivery using integrin-targeted PLGA-Chitosan nanoparticle for lung cancer therapy

A Babu, N Amreddy, R Muralidharan, G Pathuri… - Scientific reports, 2017 - nature.com
In this study, we report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified
polylactic acid-co-glycolic acid (PLGA)-Chitosan nanoparticle (CSNP) for integrin αvβ3 …