Construction of a TAN-associated risk score model with integrated multi-omics data analysis and clinical validation in gastric cancer

Z Xu, L Zhang, X Wang, B Pan, M Zhu, T Wang, W Xu… - Life Sciences, 2024 - Elsevier
Aims An increasing number of studies have highlighted the biological significance of
neutrophil activation and polarization in tumor progression. However, the characterization of …

[HTML][HTML] A novel tumor-associated neutrophil gene signature for predicting prognosis, tumor immune microenvironment, and therapeutic response in breast cancer

J Zhang, X Wang, Z Zhang, F Ma, F Wang - Scientific Reports, 2024 - nature.com
Tumor-associated neutrophils (TANs) can promote tumor progression. This study aimed to
investigate the molecular signature that predict the prognosis and immune response of …

[HTML][HTML] Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective

Y Hao, P Hu, J Zhang - Annals of translational medicine, 2020 - ncbi.nlm.nih.gov
Background Tumor-associated neutrophils (TANs) have been a research hotspot in recent
years. However, the role and relevant mechanisms of TANs in the tumor microenvironment …

A novel neutrophil extracellular traps signature for overall survival prediction and tumor microenvironment identification in gastric cancer

Z Qu, Y Han, Q Zhu, W Ding, Y Wang… - Journal of …, 2023 - Taylor & Francis
Background Neutrophil extracellular traps (NETs) released by neutrophils are crucial for
cancer development, metastasis, and can indicate gastric cancer (GC) patients' prognosis …

[HTML][HTML] Sexual dimorphism in gastric cancer: tumor-associated neutrophils predict patient outcome only for women

F Clausen, HM Behrens, S Krüger… - Journal of Cancer …, 2020 - Springer
Abstract Purpose Tumor-associated neutrophils (TANs) are part of the tumor immune
microenvironment (TIME) and may contribute to gastric cancer (GC) biology. We …

[HTML][HTML] Neoadjuvant/Perioperative treatment affects spatial distribution and densities of tumor associated neutrophils and CD8+ lymphocytes in gastric cancer

A Hoffmann, HM Behrens, S Heckl, S Krüger… - Journal of Personalized …, 2021 - mdpi.com
Tumor associated neutrophils (TANs) and cytotoxic T cells (CTLs) are part of the tumor
microenvironment of gastric cancer (GC). We explored their tumor biological significance in …

Integrated Analysis Construct a Tumor-Associated Macrophage Novel Signature with Promising Implications in Predicting the Prognosis and Immunotherapeutic …

H Xin, Y Chen, H Niu, X Li, X Gai, G Cui - Digestive Diseases and …, 2024 - Springer
Background Gastric cancer (GC) remains one of the most prevalent malignant tumors
worldwide. At present, tumor-associated macrophages (TAMs) are essential in the …

[HTML][HTML] Sex-specific prognostic effect of CD66b-positive tumor-infiltrating neutrophils (TANs) in gastric and esophageal adenocarcinoma

A Quaas, A Pamuk, S Klein, J Quantius, J Rehkaemper… - Gastric Cancer, 2021 - Springer
Abstract Background Tumor-associated neutrophils (TANs) have recently been identified as
a relevant component of the tumor microenvironment (TME) in solid tumors. Within the TME …

[HTML][HTML] Development and validation of a three-gene prognostic signature based on tumor microenvironment for gastric cancer

Q Wang, X Li, Y Wang, J Qiu, J Wu, Y He, J Li… - Frontiers in …, 2022 - frontiersin.org
Gastric cancer (GC), which has high morbidity and low survival rate, is one of the most
common malignant tumors in the world. The increasing evidences show that the tumor …

[HTML][HTML] Construction and validation of a universal applicable prognostic signature for gastric cancer based on seven immune-related gene correlated with tumor …

J Huo, L Wu, Y Zang - Frontiers in oncology, 2021 - frontiersin.org
Background Tumor-associated macrophages (TAMs) play a critical role in the progression of
malignant tumors, but the detailed mechanism of TAMs in gastric cancer (GC) is still not fully …