Transcriptional activation of many bacterial promoters in their natural environment is not a
simple on/off decision. The expression of cognate genes is integrated in layers of iterative …

Most bacterial promoters are regulated by several signals. This is reflected in the complexity
of their organization, with multiple binding sites for different transcription factors. Studies of a …

Evolutionary changes in ancestral regulatory circuits can bring about phenotypic differences
between related organisms. Studies of regulatory circuits in eukaryotes suggest that these …

Activation of the transcription of genes is central to many processes of adaptation and
differentiation in bacteria. Here, I review the molecular mechanisms by which transcription …

Related organisms typically respond to a given cue by altering the level or activity of
orthologous transcription factors, which, paradoxically, often regulate expression of distinct …

Abstract Information about the extra-or intracellular environment is often captured as
biochemical signals that propagate through regulatory networks. These signals eventually …

Transcriptional regulatory systems play a central role in coordinating bacterial responses to
diverse stimuli. These systems can be studied in progressive stages: from input signals to …

Transcription is an essential step in gene expression and its understanding has been one of
the major interests in molecular and cellular biology. By precisely tuning gene expression …

Gene expression is regulated by specific transcriptional circuits but also by the global
expression machinery as a function of growth. Simultaneous specific and global regulation …

The genomes of bacterial species show enormous plasticity in the function of individual
genes, in genome organization and in regulatory organization. Over millions of years, both …