Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …

Over the past 10 years, the development of chromosome conformation capture (3C)
technology and the subsequent genomic variants thereof have enabled the analysis of …

Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …

The relevance of three-dimensional (3D) genome organization for transcriptional regulation
and thereby for cellular fate at large is now widely accepted. Our understanding of the …

The 3D organization of the genome facilitates gene regulation, replication, and repair,
making it a key feature of genomic function and one that remains to be properly understood …

Rapidly developing technologies have recently fueled an exciting era of discovery in the
field of chromosome structure and nuclear organization. In addition to chromosome …

Recent technological advances in the field of chromosome conformation capture are
facilitating tremendous progress in the ability to map the three-dimensional (3D) …

Over a decade ago the advent of high-throughput chromosome conformation capture (Hi-C)
sparked a new era of 3D genomics. Since then the number of methods for mapping the 3D …

The three-dimensional folding of chromosomes compartmentalizes the genome and and
can bring distant functional elements, such as promoters and enhancers, into close spatial …