Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
SCS Brandao, JOX Ramos, LT Dompieri… - Cytokine & Growth …, 2021 - Elsevier
The severe form of COVID-19 is marked by an abnormal and exacerbated immunological
host response favoring to a poor outcome in a significant number of patients, especially …
host response favoring to a poor outcome in a significant number of patients, especially …
Toll-like receptors and COVID-19: a two-faced story with an exciting ending
Coronavirus disease 19 (COVID-19) is caused by a novel single-stranded RNA beta-
coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[1] …
coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[1] …
COVID‐19 and toll‐like receptor 4 (TLR4): SARS‐CoV‐2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation
MM Aboudounya, RJ Heads - Mediators of inflammation, 2021 - Wiley Online Library
Causes of mortality from COVID‐19 include respiratory failure, heart failure, and
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …
[HTML][HTML] Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic health
Abstract Obesity, type 2 diabetes (T2DM), hypertension (HTN), and Cardiovascular Disease
(CVD) often cluster together as “Cardiometabolic Disease”(CMD). Just under 50% of …
(CVD) often cluster together as “Cardiometabolic Disease”(CMD). Just under 50% of …
Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients
MCS Menezes, ADM Veiga, T Martins de Lima… - Scientific reports, 2021 - nature.com
The role of innate immunity in COVID-19 is not completely understood. Therefore, this study
explored the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) …
explored the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) …
Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19
M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
Balanced immune regulation is crucial for recognizing an invading pathogen, its killing, and
elimination. Toll‐like receptors (TLRs) are the key regulators of the innate immune system. It …
elimination. Toll‐like receptors (TLRs) are the key regulators of the innate immune system. It …
Could SARS-CoV-2-induced hyperinflammation magnify the severity of coronavirus disease (CoViD-19) leading to acute respiratory distress syndrome?
ASS Girija, EM Shankar, M Larsson - Frontiers in immunology, 2020 - frontiersin.org
The exaggerated immune response induced in the lower respiratory tract against
coronaviruses (CoVs), including CoViD-19 (2019-nCoV), appears to contribute to the …
coronaviruses (CoVs), including CoViD-19 (2019-nCoV), appears to contribute to the …
Toll-like receptor signaling in severe acute respiratory syndrome coronavirus 2-induced innate immune responses and the potential application value of toll-like …
J Dai, Y Wang, H Wang, Z Gao, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are key sensors that recognize the pathogen-associated
molecular patterns (PAMPs) of severe acute respiratory syndrome coronavirus 2 (SARS …
molecular patterns (PAMPs) of severe acute respiratory syndrome coronavirus 2 (SARS …
Role of Toll‐like receptors in the pathogenesis of COVID‐19
S Khanmohammadi, N Rezaei - Journal of medical virology, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), has led to a pandemic since March 2020. The …
syndrome coronavirus 2 (SARS‐CoV‐2), has led to a pandemic since March 2020. The …
[HTML][HTML] Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic …
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is the causative
agent of Corona Virus Disease 2019 (COVID-19). Lower production of type I and III …
agent of Corona Virus Disease 2019 (COVID-19). Lower production of type I and III …