A neuronal blood marker is associated with mortality in old age
SA Kaeser, B Lehallier, M Thinggaard, LM Häsler… - Nature Aging, 2021 - nature.com
Neurofilament light chain (NfL) has emerged as a promising blood biomarker for the
progression of various neurological diseases. NfL is a structural protein of nerve cells, and …
progression of various neurological diseases. NfL is a structural protein of nerve cells, and …
[HTML][HTML] Plasma neurofilament light chain (NfL) reference interval determination in an age-stratified cognitively unimpaired cohort
JA Bornhorst, D Figdore, MR Campbell… - Clinica Chimica …, 2022 - Elsevier
Abstract Background and Aims Neurofilament light chain (NfL) is an emerging biomarker of
neurodegenerative disease progression. As plasma NfL increases with age …
neurodegenerative disease progression. As plasma NfL increases with age …
Serum neurofilament light levels are predictive of all-cause mortality in late middle-aged individuals
AD Nguyen, TK Malmstrom, G Aggarwal, DK Miller… - …, 2022 - thelancet.com
Background Blood biomarkers can offer valuable and easily accessible indicators of normal
biological processes, pathogenic conditions, and responses to therapeutic interventions …
biological processes, pathogenic conditions, and responses to therapeutic interventions …
[HTML][HTML] Neurofilament light chain plasma concentration predicts neurodegeneration and clinical progression in nondemented elderly adults
H Hu, KL Chen, YN Ou, XP Cao, SD Chen… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Previous studies demonstrated that plasma neurofilament light chain (NFL) played important
predictive roles in disease progression and neurodegeneration in the preclinical phase of …
predictive roles in disease progression and neurodegeneration in the preclinical phase of …
The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease
Y Jung, JS Damoiseaux - Brain, 2024 - academic.oup.com
Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …
Increased neurofilament light chain blood levels in neurodegenerative neurological diseases
Objective Neuronal damage is the morphological substrate of persisting neurological
disability. Neurofilaments (Nf) are cytoskeletal proteins of neurons and their release into …
disability. Neurofilaments (Nf) are cytoskeletal proteins of neurons and their release into …
Association of neurofilament light chain with renal function: mechanisms and clinical implications
Background Blood-based neurofilament light chain (NfL) is a promising biomarker of
neurodegeneration across multiple neurodegenerative diseases. However, blood-based …
neurodegeneration across multiple neurodegenerative diseases. However, blood-based …
Serum neurofilament light chain and cognition decline in US elderly: A cross‐sectional study
X Liu, J Chen, C Meng, L Zhou… - Annals of Clinical and …, 2024 - Wiley Online Library
Objective Early identification of cognitive impairment in neurodegenerative diseases like
Alzheimer's disease (AD) is crucial. Neurofilament, a potential biomarker for neurological …
Alzheimer's disease (AD) is crucial. Neurofilament, a potential biomarker for neurological …
Renal function is associated with blood neurofilament light chain level in older adults
S Akamine, N Marutani, D Kanayama, S Gotoh… - Scientific reports, 2020 - nature.com
Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is
detectable in the peripheral blood, allowing low-invasive assessment of early signs of …
detectable in the peripheral blood, allowing low-invasive assessment of early signs of …
Serum neurofilament light levels in normal aging and their association with morphologic brain changes
M Khalil, L Pirpamer, E Hofer, MM Voortman… - Nature …, 2020 - nature.com
Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured
not only in cerebrospinal fluid but also in serum, which allows for repeated assessments …
not only in cerebrospinal fluid but also in serum, which allows for repeated assessments …