A neuronal blood marker is associated with mortality in old age

SA Kaeser, B Lehallier, M Thinggaard, LM Häsler… - Nature Aging, 2021 - nature.com
Neurofilament light chain (NfL) has emerged as a promising blood biomarker for the
progression of various neurological diseases. NfL is a structural protein of nerve cells, and …

[HTML][HTML] Plasma neurofilament light chain (NfL) reference interval determination in an age-stratified cognitively unimpaired cohort

JA Bornhorst, D Figdore, MR Campbell… - Clinica Chimica …, 2022 - Elsevier
Abstract Background and Aims Neurofilament light chain (NfL) is an emerging biomarker of
neurodegenerative disease progression. As plasma NfL increases with age …

Serum neurofilament light levels are predictive of all-cause mortality in late middle-aged individuals

AD Nguyen, TK Malmstrom, G Aggarwal, DK Miller… - …, 2022 - thelancet.com
Background Blood biomarkers can offer valuable and easily accessible indicators of normal
biological processes, pathogenic conditions, and responses to therapeutic interventions …

[HTML][HTML] Neurofilament light chain plasma concentration predicts neurodegeneration and clinical progression in nondemented elderly adults

H Hu, KL Chen, YN Ou, XP Cao, SD Chen… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Previous studies demonstrated that plasma neurofilament light chain (NFL) played important
predictive roles in disease progression and neurodegeneration in the preclinical phase of …

The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease

Y Jung, JS Damoiseaux - Brain, 2024 - academic.oup.com
Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …

Increased neurofilament light chain blood levels in neurodegenerative neurological diseases

J Gaiottino, N Norgren, R Dobson, J Topping, A Nissim… - PloS one, 2013 - journals.plos.org
Objective Neuronal damage is the morphological substrate of persisting neurological
disability. Neurofilaments (Nf) are cytoskeletal proteins of neurons and their release into …

Association of neurofilament light chain with renal function: mechanisms and clinical implications

R Tang, MS Panizzon, JA Elman, NA Gillespie… - Alzheimer's Research & …, 2022 - Springer
Background Blood-based neurofilament light chain (NfL) is a promising biomarker of
neurodegeneration across multiple neurodegenerative diseases. However, blood-based …

Serum neurofilament light chain and cognition decline in US elderly: A cross‐sectional study

X Liu, J Chen, C Meng, L Zhou… - Annals of Clinical and …, 2024 - Wiley Online Library
Objective Early identification of cognitive impairment in neurodegenerative diseases like
Alzheimer's disease (AD) is crucial. Neurofilament, a potential biomarker for neurological …

Renal function is associated with blood neurofilament light chain level in older adults

S Akamine, N Marutani, D Kanayama, S Gotoh… - Scientific reports, 2020 - nature.com
Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is
detectable in the peripheral blood, allowing low-invasive assessment of early signs of …

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

M Khalil, L Pirpamer, E Hofer, MM Voortman… - Nature …, 2020 - nature.com
Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured
not only in cerebrospinal fluid but also in serum, which allows for repeated assessments …