Current perspectives on “off-the-shelf” allogeneic NK and CAR-NK cell therapies

EL Heipertz, ER Zynda, TE Stav-Noraas… - Frontiers in …, 2021 - frontiersin.org
Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily
located in peripheral circulation and lymphoid tissues. They kill virally infected and …

[HTML][HTML] The application of natural killer cell immunotherapy for the treatment of cancer

K Rezvani, RH Rouce - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are essential components of the innate immune system and play a
critical role in host immunity against cancer. Recent progress in our understanding of NK cell …

Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy

F Marofi, HS Rahman, L Thangavelu… - Stem cell research & …, 2021 - Springer
In recent decades, a new method of cellular immunotherapy was introduced based on
engineering and empowering the immune effector cells. In this type of immunotherapy, the …

Natural born killers: NK cells in cancer therapy

SE Franks, B Wolfson, JW Hodge - Cancers, 2020 - mdpi.com
Cellular therapy has emerged as an attractive option for the treatment of cancer, and
adoptive transfer of chimeric antigen receptor (CAR) expressing T cells has gained FDA …

Natural killer cells in clinical development as non-engineered, engineered, and combination therapies

N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …

CAR-NK cells for cancer immunotherapy: from bench to bedside

L Zhang, Y Meng, X Feng, Z Han - Biomarker Research, 2022 - Springer
Natural killer (NK) cells are unique innate immune cells and manifest rapid and potent
cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of …

[HTML][HTML] Cancer immunotherapy based on natural killer cells: current progress and new opportunities

W Hu, G Wang, D Huang, M Sui, Y Xu - Frontiers in immunology, 2019 - frontiersin.org
Cancer immunotherapy has been firmly established as a new milestone for cancer therapy,
with the development of multiple immune cells as therapeutic tools. Natural killer (NK) cells …

Chimeric antigen receptor-engineered natural killer (CAR NK) cells in cancer treatment; recent advances and future prospects

R Elahi, AH Heidary, K Hadiloo… - Stem Cell Reviews and …, 2021 - Springer
Natural Killer (NK) cells are critical members of the innate immunity lymphocytes and have a
critical role in host defense against malignant cells. Adoptive cell therapy (ACT) using …

[HTML][HTML] The rise of allogeneic natural killer cells as a platform for cancer immunotherapy: recent innovations and future developments

JP Veluchamy, N Kok, HJ van der Vliet… - Frontiers in …, 2017 - frontiersin.org
Natural killer (NK) cells are critical immune effector cells in the fight against cancer. As NK
cells in cancer patients are highly dysfunctional and reduced in number, adoptive transfer of …

Natural killer cells: a promising immunotherapy for cancer

J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …