Therapy discontinuation or substitution in patients with cardiovascular disease, switching among different products of the same off-patent active substance: a 'real …

L Degli Esposti, D Sangiorgi, S Buda, E Degli Esposti… - BMJ open, 2016 - bmjopen.bmj.com
Objective The present study investigated the effects of switching to different products of the
same off-patent active substance (brand name or generic) on therapy discontinuation or …

Switching among equivalents in chronic cardiovascular therapies:'real world'data from Italy

E Poluzzi, G Veronese, C Piccinni… - Basic & clinical …, 2016 - Wiley Online Library
Abstract Since August 2012, Italian general practitioners are required to prescribe the
generic name of medicines, except for refill of chronic therapy. We evaluated the extent of …

[HTML][HTML] Impact of substitution among generic drugs on persistence and adherence: a retrospective claims data study from 2 local healthcare units in the Lombardy …

GL Colombo, E Agabiti-Rosei, A Margonato… - Atherosclerosis …, 2016 - Elsevier
Background The use of generics, equivalent but less expensive drugs, is an important
opportunity to reduce healthcare expenditure. Methods The purpose of this study was to …

Generic-to-branded drug switch-back patterns: exploratory analysis and insights from the statin class

GA Chressanthis, P Khedkar, N Jain… - Journal of …, 2011 - academic.oup.com
Objectives This paper analyses generic-to-branded drug switch-back patterns in the statin
class. Methods Utilizing LifeLink™ Anonymized Patient Level Data (APLD) from IMS Health …

Challenges of therapeutic substitution of drugs for economic reasons: focus on CVD prevention

A Johnston - Current medical research and opinion, 2010 - Taylor & Francis
Background: Healthcare systems throughout the world are under increasing pressure to
control and minimise costs. The substitution of initially-prescribed drugs with cheaper …

Prior experience with cardiovascular medicines predicted longer persistence in people initiated to combinations of antihypertensive and lipid-lowering therapies …

LE Bartlett, NL Pratt, EE Roughead - Patient preference and …, 2018 - Taylor & Francis
Purpose Many studies of persistence involving fixed dose combinations (FDCs) of
cardiovascular medicines have not adequately accounted for a user's prior experience with …

[HTML][HTML] Factors influencing drug switching and changes in low-density lipoprotein-cholesterol levels with atorvastatin: a real-world observational study

YC Lim, EK Lee, MH Park - Lipids in Health and Disease, 2023 - Springer
Background Although generic drugs have been approved with the assurance of
interchangeable applications with original drugs, some physicians, and patients still view …

Generic substitution of commonly used medications: Australia‐wide experience, 2007–2008

M Ortiz, LA Simons, G Calcino - Medical Journal of Australia, 2010 - Wiley Online Library
Objective: To study the extent of brand substitution and switching in three commonly used
classes of drugs available on the Pharmaceutical Benefits Scheme (PBS). Design, setting …

Evaluation of the clinical outcomes of switching patients from atorvastatin to simvastatin and losartan to candesartan in a primary care setting: 2 years on

J Usher‐Smith, T Ramsbottom… - … journal of clinical …, 2008 - Wiley Online Library
Aims: This short report was designed to provide 2‐year follow‐up data from a previous study
carried out in a primary care practice in the UK to assess the clinical and practical …

Persistence and cardiovascular outcomes with ramipril, atorvastatin, ASA as a single pill compared to the multi pill combination. A subanalysis of the START study, a …

HG Predel, B Weisser, S Wassmann… - European Heart …, 2020 - academic.oup.com
Abstract Background/Introduction Large randomized clinical trials have shown the efficacy of
aspirin (ASA), angiotensin converting enzyme inhibitors (ACEI) and statins (S) in secondary …