Elevated levels of saturated very long-chain fatty acids (VLCFAs) in cell membranes and
secreted lipoparticles have been associated with neurotoxicity and, therefore, require tight …

Saturated very long-chain fatty acids (VLCFA,≥ C22), enriched in brain myelin and innate
immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due to inherited …

Microglia are crucial for brain homeostasis, and dysfunction of these cells is a key driver in
most neurodegenerative diseases, including peroxisomal leukodystrophies. In X-linked …

Peroxisomes are organelles responsible for multiple metabolic pathways including, the
biosynthesis of plasmalogens, a class of phospholipids, and the β-oxidation of very-long …

X-linked adrenoleukodystrophy (X-ALD) and pseudo neonatal adrenoleukodystrophy (P-
NALD) are neurodegenerative demyelinating diseases resulting from the functional loss of …

Saturated very long chain fatty acids (VLCFAs;≥ C22: 0) accumulate in X-linked
adrenoleukodystrophy (X-ALD, OMIM 300100), a severe hereditary neurodegenerative …

The accumulation of saturated very long-chain fatty acids (VLCFA,≥ C22: 0) due to
peroxisomal impairment leads to oxidative stress and neurodegeneration in X-linked …

Background Deterioration of peroxisomal β-oxidation activity causes an accumulation of
very long chain saturated fatty acids (VLCSFA) in various organs. We have recently reported …

Peroxisomes are ubiquitous subcellular organelles and abnormality in their biogenesis and
specific gene defects leads to fatal demyelinating disorders. We report that …

Metabolism has been shown to control peripheral immunity, but little is known about its role
in central nervous system (CNS) inflammation. Through a combination of proteomic …