Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract

NN Nkwanyana, PP Gumbi, L Roberts, L Denny… - …, 2009 - Wiley Online Library
Cervical cytobrush sampling is a relatively non‐invasive method for obtaining mucosal cells
from the female genital tract. To define mucosal immune cells sampled by cervical …

Changes to the cytokine microenvironment in the genital tract mucosa of HIV+ women

Olaitan, Reid, Poulter - Clinical & Experimental Immunology, 1998 - Wiley Online Library
As previous studies have indicated that genital tract mucosal T cell function may be impaired
in HIV infection, we investigated the T cell cytokine mRNA in the genital tract mucosa of HIV …

CD4 T cell depletion at the cervix during HIV infection is associated with accumulation of terminally differentiated T cells

PP Gumbi, SZ Jaumdally, AL Salkinder… - Journal of …, 2011 - Am Soc Microbiol
In blood, the accumulation of terminally differentiated (TD) T cells during HIV infection is
associated with CD4 T cell loss and HIV disease progression. Here, we investigated the …

[HTML][HTML] Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected women

A Bere, L Denny, W Hanekom, WA Burgers… - Journal of …, 2010 - Elsevier
Cervical cytobrushing is a useful and non-invasive method for obtaining mucosal
mononuclear cells from the female genital tract, but yields few cells. The aim of this study …

Immunity in the female lower genital tract and the impact of HIV infection

SM Ahmed, H Al‐Doujaily, MA Johnson… - Scandinavian …, 2001 - Wiley Online Library
This study investigates the distribution of immunocompetent cells in the ectocervix, and
cytokine and immunoglobulin (Ig) levels in cervicovaginal secretions to determine whether …

Evaluation of immunologic markers in cervicovaginal fluid of HIV-infected and uninfected women: implications for the immunologic response to HIV in the female …

ES Beverly, RD D'Amico, AL Landay… - JAIDS Journal of …, 1997 - journals.lww.com
We analyzed 21 cervicovaginal lavage (CVL) specimens from 19 women participating in the
Women's Interagency HIV Study to characterize levels of antibody, cytokine, and …

The distribution of immunocompetent cells in the genital tract of HIV-positive women

A Olaitan, MA Johnson, A MacLean, LW Poulter - Aids, 1996 - journals.lww.com
Objective: To study the distribution of immunocompetent cells in the female lower genital
tract and to determine whether it is altered in HIV infection. Methods: Colposcopically …

Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV …

PP Gumbi, NN Nkwanyana, A Bere… - Journal of …, 2008 - Am Soc Microbiol
The female genital tract is the major route of heterosexual human immunodeficiency virus
(HIV) acquisition and transmission. Here, we investigated whether HIV-specific CD8 T-cell …

Distribution of immune cells in the human cervix and implications for HIV transmission

RT Trifonova, J Lieberman… - American journal of …, 2014 - Wiley Online Library
Problem Knowledge of the mucosal immune cell composition of the human female genital
tract is important for understanding susceptibility to HIV‐1. Method of study We developed …

The impact of cervical cytobrush sampling on cervico-vaginal immune parameters and microbiota relevant to HIV susceptibility

A Mohammadi, S Bagherichimeh, MC Perry, A Fazel… - Scientific Reports, 2020 - nature.com
The immunology and microbiota of the female genital tract (FGT) are key determinants of
HIV susceptibility. Cervical cytobrush sampling is a relatively non-invasive method …