Type I IFNs play a critical role in the immune response to viral infection and may also drive
autoimmunity through modulation of monocyte maturation and promotion of autoreactive …

IFNs are well known as mediators of the antimicrobial response but also serve as important
immunomodulatory cytokines in autoimmune and autoinflammatory diseases. An …

Type I IFNs are implicated in the pathophysiology of systemic sclerosis (SSc). Recently, a
Phase I open-label trial was conducted with an anti-IFNAR1 receptor antibody (anifrolumab) …

Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of
autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and …

Type I IFNs are a family of proinflammatory cytokines that are essential for antiviral immunity
but whose overexpression is associated with several autoimmune disorders. In this study …

Phototherapy with UV light is a standard treatment for psoriasis, yet the mechanisms
underlying the therapeutic effects are not well understood. Studies in human and mouse …

Psoriasis is an inflammatory skin disease, onset and severity of which are controlled by
multiple genetic factors; aberrant expression of and responses to several cytokines including …

Activation of TLR3 by exogenous microbial ligands or endogenous injury-associated ligands
leads to production of type I IFN. Scleroderma patients with progressive skin fibrosis display …

Psoriasis is a common, inflammatory autoimmune skin disease. Early detection of an IFN-1
signature occurs in many psoriasis lesions, but the source of IFN production remains …

Type I interferons (IFN-α/β) are produced upon viral and bacterial infections and play
essential roles in host defense. However, since IFN-α/β have multiple regulatory functions …