Macrophages (MΦ) play pivotal roles in tissue homeostasis and repair. Their mechanical
environment has been identified as a key modulator of various cell functions, and MΦ …

Macrophages are the most important innate immune cells in humans. They are almost
ubiquitous in peripheral tissues with a large variety of different mechanical milieus …

Piezo1 is a mechanosensitive cation channel with widespread physiological importance;
however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve …

Background: Angiogenesis is a promising strategy for those with peripheral artery disease.
Macrophage-centered inflammation is intended to govern the deficiency of the angiogenic …

The immune system performs critical functions to defend against invading pathogens and
maintain tissue homeostasis. Immune cells reside within or are recruited to a host of …

Mechanotransduction is the conversion of extracellular mechanical stimuli into intracellular
biochemical signals, and plays an important role in heart responses to its own mechanical …

The mechanical environment of cardiac cells changes continuously and undergoes major
alterations during diseases. Most cardiac diseases, including atrial fibrillation, are …

Piezo1 senses pressure overload and initiates cardiac hypertrophy | Nature Reviews Cardiology
Skip to main content Thank you for visiting nature.com. You are using a browser version with …

The transformation of electrical signals into mechanical action of the heart underlying blood
circulation results in mechanical stimuli during active contraction or passive filling distention …

Stretch-activated or mechanosensitive channels transduce mechanical forces into ion fluxes
across the cell membrane. These channels have been implicated in several aspects of …