[HTML][HTML] Atrial fibrillation: mechanisms, therapeutics, and future directions

J Pellman, F Sheikh - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, affecting 1% to 2% of the
general population. It is characterized by rapid and disorganized atrial activation leading to …

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

J Heijman, V Algalarrondo, N Voigt… - Cardiovascular …, 2016 - academic.oup.com
Atrial fibrillation (AF) is an extremely common clinical problem associated with increased
morbidity and mortality. Current antiarrhythmic options include pharmacological, ablation …

Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …

[HTML][HTML] Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation

R Pathak, DH Lau, R Mahajan… - Journal of atrial …, 2013 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice.
Despite advances in our understanding of the pathophysiology of this complex arrhythmia …

Atrial remodeling and atrial fibrillation: mechanisms and implications

S Nattel, B Burstein, D Dobrev - Circulation: Arrhythmia and …, 2008 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any
age but is very rare in children and becomes extremely common in the elderly, with a …

Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?

S Nattel - Cardiovascular research, 2002 - academic.oup.com
Atrial fibrillation (AF) is a very common clinical problem, and presently available treatment
options are suboptimal. A tremendous amount has been learned over the past 10 years …

Atrial fibrillation pathophysiology: implications for management

Y Iwasaki, K Nishida, T Kato, S Nattel - Circulation, 2011 - Am Heart Assoc
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important
contributor to population morbidity and mortality. An arrhythmia that is particularly common …

Atrial remodeling in varying clinical substrates within beating human hearts: relevance to atrial fibrillation

S Kumar, AW Teh, C Medi, PM Kistler, JB Morton… - Progress in Biophysics …, 2012 - Elsevier
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in human beating
hearts. AF initiates self-perpetuating changes in electrophysiology, structure and functional …

Dynamics of atrial fibrillation mechanisms and comorbidities

J Heijman, D Linz, U Schotten - Annual review of physiology, 2021 - annualreviews.org
Atrial fibrillation (AF) contributes to morbidity and mortality of millions of individuals. Its
molecular, cellular, neurohumoral, and hemodynamic pathophysiological mechanisms are …