Increased number and activity of a lateral subpopulation of hypothalamic orexin/hypocretin neurons underlies the expression of an addicted state in rats
Background The orexin (hypocretin) system is important for reward-driven motivation but has
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …
A septal-hypothalamic pathway drives orexin neurons, which is necessary for conditioned cocaine preference
GC Sartor, GS Aston-Jones - Journal of Neuroscience, 2012 - Soc Neuroscience
Orexins (also called hypocretins) have been shown to be importantly involved in reward and
addiction, but little is known about the circuitry that regulates orexin neuronal activity during …
addiction, but little is known about the circuitry that regulates orexin neuronal activity during …
Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell
R Sharf, M Sarhan, RJ DiLeone - Biological psychiatry, 2008 - Elsevier
BACKGROUND: The lateral hypothalamic neuropeptide orexin (or hypocretin) is implicated
in drug addiction. Although a role for orexin has been shown in reward and dependence, the …
in drug addiction. Although a role for orexin has been shown in reward and dependence, the …
Orexin reserve: a mechanistic framework for the role of orexins (hypocretins) in addiction
MH James, G Aston-Jones - Biological psychiatry, 2022 - Elsevier
In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …
Role of orexin/hypocretin in dependence and addiction
R Sharf, M Sarhan, RJ DiLeone - Brain research, 2010 - Elsevier
The orexins (or hypocretins) are hypothalamic neuropeptides that have been implicated in a
variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal …
variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal …
Orexin/hypocretin is necessary for context-driven cocaine-seeking
Orexin/hypocretin signaling at the orexin 1 receptor (OX1R) has recently been implicated in
addiction and relapse. We examined the role of the orexin system in cocaine-seeking …
addiction and relapse. We examined the role of the orexin system in cocaine-seeking …
Multiple roles for orexin/hypocretin in addiction
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
Orexin‐1 receptor signaling increases motivation for cocaine‐associated cues
BS Bentzley, G Aston‐Jones - European Journal of …, 2015 - Wiley Online Library
The orexin/hypocretin system is involved in multiple cocaine addiction processes that
involve drug‐associated environmental cues, including cue‐induced reinstatement of …
involve drug‐associated environmental cues, including cue‐induced reinstatement of …
[图书][B] A decade of orexin/hypocretin and addiction: where are we now?
One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …
signaling with drug seeking by showing that activation of these neurons promotes …
Orexin/hypocretin role in reward: implications for opioid and other addictions
Addiction is a devastating disorder that affects 15.3 million people worldwide. While
prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential …
prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential …