Neuroinflammation in the prefrontal-amygdala-hippocampus network is associated with maladaptive avoidance behaviour
GF Antunes, FV Gouveia, MA Kuroki, DO Martins… - Heliyon, 2024 - cell.com
Maladaptive avoidance behaviour is often observed in patients suffering from anxiety and
trauma-and stressor-related disorders. The prefrontal-amygdala-hippocampus network is …
trauma-and stressor-related disorders. The prefrontal-amygdala-hippocampus network is …
Altered activity of the medial prefrontal cortex and amygdala during acquisition and extinction of an active avoidance task
Altered medial prefrontal cortex (mPFC) and amygdala function is associated with anxiety-
related disorders. While the mPFC-amygdala pathway has a clear role in fear conditioning …
related disorders. While the mPFC-amygdala pathway has a clear role in fear conditioning …
The role of the hippocampus in avoidance learning and anxiety vulnerability
TP Cominski, X Jiao, JE Catuzzi, AL Stewart… - Frontiers in behavioral …, 2014 - frontiersin.org
The hippocampus has been implicated in anxiety disorders and post-traumatic stress
disorder (PTSD); human studies suggest that a dysfunctional hippocampus may be a …
disorder (PTSD); human studies suggest that a dysfunctional hippocampus may be a …
[HTML][HTML] Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation
F Yasuno, Y Kimura, A Ogata, H Ikenuma, J Abe… - Brain, Behavior, & …, 2024 - Elsevier
Background Positron emission tomography, which assesses the binding of translocator
protein radiotracers, 11 C-DPA-713, may be a sensitive method for determining glial …
protein radiotracers, 11 C-DPA-713, may be a sensitive method for determining glial …
Enriched environment attenuates enhanced trait anxiety in association with normalization of aberrant neuro-inflammatory events
A Sah, S Rooney, M Kharitonova, SB Sartori… - International Journal of …, 2022 - mdpi.com
Neuroinflammation is discussed to play a role in specific subgroups of different psychiatric
disorders, including anxiety disorders. We have previously shown that a mouse model of …
disorders, including anxiety disorders. We have previously shown that a mouse model of …
Inflammation modulates anxiety in an animal model of multiple sclerosis
I Peruga, S Hartwig, J Thöne, B Hovemann… - Behavioural brain …, 2011 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) characterized by inflammation, but also degenerative changes. Besides neurological …
(CNS) characterized by inflammation, but also degenerative changes. Besides neurological …
Neuroimaging the temporal dynamics of human avoidance to sustained threat
MW Schlund, CD Hudgins, S Magee… - Behavioural brain …, 2013 - Elsevier
Many forms of human psychopathology are characterized by sustained negative emotional
responses to threat and chronic behavioral avoidance, implicating avoidance as a potential …
responses to threat and chronic behavioral avoidance, implicating avoidance as a potential …
Cortico-limbic connectivity changes following fear extinction and relationships with trait anxiety
EL Belleau, WS Pedersen, TA Miskovich… - Social Cognitive and …, 2018 - academic.oup.com
Fear extinction is a powerful model of adaptive and anxiety-related maladaptive fear
inhibition. This learning process is dependent upon plastic interactions between the …
inhibition. This learning process is dependent upon plastic interactions between the …
Avoidance: From basic science to psychopathology
RJ Servatius - Frontiers in Behavioral Neuroscience, 2016 - frontiersin.org
As a means of coping, avoidance encompasses thoughts and efforts toward prevention of
future aversive experiences and events. Avoidance has been and remains controversial …
future aversive experiences and events. Avoidance has been and remains controversial …
Human avoidance and approach learning: evidence for overlapping neural systems and experiential avoidance modulation of avoidance neurocircuitry
MW Schlund, S Magee, CD Hudgins - Behavioural brain research, 2011 - Elsevier
Adaptive functioning is thought to reflect a balance between approach and avoidance neural
systems with imbalances often producing pathological forms of avoidance. Yet little …
systems with imbalances often producing pathological forms of avoidance. Yet little …