DNA damage can alter nucleotide sequences and lead to expression of dysfunctional
proteins that impact normal cellular physiology. Sources of DNA damage can be …

DNA is under constant assault from genotoxic agents which creates different kinds of DNA
damage. The precise replication of the genome and the continuous surveillance of its …

Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

DNA damage has been long recognized as causal factor for cancer development. When
erroneous DNA repair leads to mutations or chromosomal aberrations affecting oncogenes …

The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

DNA is subjected to several modifications, resulting from endogenous and exogenous
sources. The cell has developed a network of complementary DNA-repair mechanisms, and …

DNA lesions and the repair mechanisms that maintain the integrity of genomic DNA are
important in preventing carcinogenesis and its progression. Notably, mutations in DNA …

DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage
exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

Advanced cancer is a leading cause of death in the developed world. Chemotherapy and
radiation are the two main treatment modalities currently available. The cytotoxicity of many …