Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

DNA double-strand breaks are the critical lesions responsible for the majority of ionizing
radiation–induced cell killing. Thus, the ability of tumor cells to elicit a DNA damage …

The DNA damage response (DDR) is a series of pathways and processes required to repair
lesions to DNA. These pathways range from repairing strand breaks to the double helix …

Cellular responses to DNA damage are important determinants of both cancer development
and cancer outcome following radiation therapy and chemotherapy. Identification of …

More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …

DNA damage-inducing therapies are of tremendous value for cancer treatment and function
by the direct or indirect formation of DNA lesions and subsequent inhibition of cellular …

The DNA damage response (DDR) is essential for maintaining the genomic integrity of the
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …

The cellular response to DNA damage is critical for determining whether carcinogenesis,
cell death or other deleterious biological effects will ensue. Numerous cellular enzymatic …

Genomic stability depends on an efficient DNA damage repair system to keep the
chromosomes intact. Unrepaired DNA damage not only causes cell cycle arrest, apoptosis …

Simple Summary The DNA damage response pathway plays a critical role in maintaining
genomic integrity. Therefore, inhibition of activation of cell-cycle checkpoints involved in this …