[HTML][HTML] DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Molecular pathways: overcoming radiation resistance by targeting DNA damage response pathways

MA Morgan, TS Lawrence - Clinical Cancer Research, 2015 - AACR
DNA double-strand breaks are the critical lesions responsible for the majority of ionizing
radiation–induced cell killing. Thus, the ability of tumor cells to elicit a DNA damage …

Advances in therapeutic targeting of the DNA damage response in cancer

A Desai, Y Yan, SL Gerson - DNA repair, 2018 - Elsevier
The DNA damage response (DDR) is a series of pathways and processes required to repair
lesions to DNA. These pathways range from repairing strand breaks to the double helix …

The DNA damage response: implications for tumor responses to radiation and chemotherapy

M Goldstein, MB Kastan - Annual review of medicine, 2015 - annualreviews.org
Cellular responses to DNA damage are important determinants of both cancer development
and cancer outcome following radiation therapy and chemotherapy. Identification of …

[HTML][HTML] Targeting DNA double-strand break repair pathways to improve radiotherapy response

M Toulany - Genes, 2019 - mdpi.com
More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …

[HTML][HTML] DNA damage-inducing anticancer therapies: from global to precision damage

TGA Reuvers, R Kanaar, J Nonnekens - Cancers, 2020 - mdpi.com
DNA damage-inducing therapies are of tremendous value for cancer treatment and function
by the direct or indirect formation of DNA lesions and subsequent inhibition of cellular …

Therapeutic opportunities within the DNA damage response

LH Pearl, AC Schierz, SE Ward, B Al-Lazikani… - Nature Reviews …, 2015 - nature.com
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …

DNA damage repair and response proteins as targets for cancer therapy

HB Lieberman - Current medicinal chemistry, 2008 - ingentaconnect.com
The cellular response to DNA damage is critical for determining whether carcinogenesis,
cell death or other deleterious biological effects will ensue. Numerous cellular enzymatic …

DNA damage response–a double-edged sword in cancer prevention and cancer therapy

H Tian, Z Gao, HZ Li, BF Zhang, G Wang, Q Zhang… - Cancer letters, 2015 - Elsevier
Genomic stability depends on an efficient DNA damage repair system to keep the
chromosomes intact. Unrepaired DNA damage not only causes cell cycle arrest, apoptosis …

The future of radiobiology

DG Kirsch, M Diehn, AH Kesarwala… - JNCI: Journal of the …, 2018 - academic.oup.com
Innovation and progress in radiation oncology depend on discovery and insights realized
through research in radiation biology. Radiobiology research has led to fundamental …