An ultra‐high pressure liquid chromatography high‐resolution mass spectrometric (UHPLC–
HRMS) method was developed for the simultaneous and sensitive quantification of 10 β …

Background: Optimization of antimicrobial therapy is a challenge in critically ill patients who
develop extreme interindividual and intraindividual pharmacokinetic variability. Therapeutic …

There is strong evidence in literature supporting the benefit of monitoring plasma
concentrations of β-lactam antibiotics in the critically ill to ensure appropriateness of dosing …

There is an increasing interest in monitoring plasma concentrations of β-lactam antibiotics.
The objective of this work was to develop and validate a rapid ultra-performance liquid …

There is an increasing interest in monitoring plasma concentrations of β-lactam antibiotics.
The objective of this work was to develop and validate a fast ultra-performance liquid …

Quantification of beta-lactam antibiotics can be performed by using liquid chromatography in
combination with tandem mass spectrometry (MS/MS) or ultraviolet (UV) detection. Since …

Contemporary β-lactam antibiotic dosing is debatable in severely ill patients, since the
occurrence of pathophysiological changes in critical illness can result in great inter …

Monitoring of plasma antibiotic concentrations is necessary for individualization of
antimicrobial chemotherapy dosing in special patient populations. One of these special …

Background The administration of β-lactam antibiotics in continuous infusion could let
optimize the pharmacokinetic/pharmacodynamic parameters, especially in the treatment of …

Antibiotic therapy is a crucial aspect of the management of hospitalized patients, however,
current standard dosing protocols have been shown to often attain inadequate plasmatic …