[HTML][HTML] Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
AM Joussen, F Ricci, LP Paris, C Korn… - Eye, 2021 - nature.com
The ang opoietin/t yrosine kinase with i mmunoglobulin and e pidermal growth factor
homology domains (Ang/Tie) pathway is an emerging key regulator in vascular development …
homology domains (Ang/Tie) pathway is an emerging key regulator in vascular development …
[HTML][HTML] Therapeutic targeting of the angiopoietin–TIE pathway
P Saharinen, L Eklund, K Alitalo - Nature Reviews Drug Discovery, 2017 - nature.com
The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …
permeability and pathological vascular remodelling during inflammation, tumour …
[HTML][HTML] The angiopoietin/tie pathway in retinal vascular diseases: a review
Purpose: To provide a concise overview for ophthalmologists and practicing retina
specialists of available clinical evidence of manipulating the angiopoietin/tyrosine kinase …
specialists of available clinical evidence of manipulating the angiopoietin/tyrosine kinase …
Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo
IB Lobov, PC Brooks, RA Lang - Proceedings of the …, 2002 - National Acad Sciences
Modulation of Tie2 receptor activity by its angiopoietin ligands is crucial for angiogenesis,
blood vessel maturation, and vascular endothelium integrity. It has been proposed that …
blood vessel maturation, and vascular endothelium integrity. It has been proposed that …
[HTML][HTML] Targeting angiopoietin in retinal vascular diseases: a literature review and summary of clinical trials involving faricimab
This review summarizes the latest findings in the literature of Angiopoietin-2 (Ang-2),
Tyrosine-protein kinase receptor (Tie-2) complex, and faricimab along with their involvement …
Tyrosine-protein kinase receptor (Tie-2) complex, and faricimab along with their involvement …
Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems
L Eklund, J Kangas, P Saharinen - Clinical Science, 2017 - portlandpress.com
Endothelial cells that form the inner layer of blood and lymphatic vessels are important
regulators of vascular functions and centrally involved in the pathogenesis of vascular …
regulators of vascular functions and centrally involved in the pathogenesis of vascular …
[HTML][HTML] Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature
Retinal and choroidal neovascularization (NV) and vascular leakage contribute to visual
impairment in several common ocular diseases. The angiopoietin/TIE2 (ANG/TIE2) pathway …
impairment in several common ocular diseases. The angiopoietin/TIE2 (ANG/TIE2) pathway …
Angiopoietin signaling in the vasculature
L Eklund, P Saharinen - Experimental cell research, 2013 - Elsevier
The angiopoietin (Ang) growth factors and the endothelial Tie receptors regulate blood and
lymphatic vessel development, and vascular permeability, inflammation, angiogenic …
lymphatic vessel development, and vascular permeability, inflammation, angiogenic …
[HTML][HTML] Potential role of the angiopoietin/tie2 system in ischemia-induced retinal neovascularization
H Takagi, S Koyama, H Seike, H Oh… - … & visual science, 2003 - arvojournals.org
purpose. Ischemia-induced neovascularization can cause catastrophic loss of vision in
retinal disorders such as diabetic retinopathy. Recent studies have shown that the …
retinal disorders such as diabetic retinopathy. Recent studies have shown that the …
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases
L Ferro Desideri, CE Traverso… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Several approaches have been investigated for treating wet age-related
macular degeneration (w-AMD), diabetic macular edema (DME) and retinal vein occlusions …
macular degeneration (w-AMD), diabetic macular edema (DME) and retinal vein occlusions …