Implementing landscape genetics in molecular epidemiology to determine drivers of vector‐borne disease: A malaria case study

A Hubbard, E Hemming‐Schroeder… - Molecular …, 2023 - Wiley Online Library
This study employs landscape genetics to investigate the environmental drivers of a deadly
vector‐borne disease, malaria caused by Plasmodium falciparum, in a more spatially …

Within‐household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda

J Briggs, A Kuchta, M Murphy, S Tessema, E Arinaitwe… - Malaria journal, 2021 - Springer
Background Evaluation of genetic relatedness of malaria parasites is a useful tool for
understanding transmission patterns, but patterns are not easily detectable in areas with …

Plasmodium falciparum genomic surveillance reveals spatial and temporal trends, association of genetic and physical distance, and household clustering

M Sy, AB Deme, JL Warren, A Early, S Schaffner… - Scientific reports, 2022 - nature.com
Molecular epidemiology using genomic data can help identify relationships between malaria
parasite population structure, malaria transmission intensity, and ultimately help generate …

Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent

AR Taylor, SF Schaffner, GC Cerqueira… - PLoS …, 2017 - journals.plos.org
With the rapidly increasing abundance and accessibility of genomic data, there is a growing
interest in using population genetic approaches to characterize fine-scale dispersal of …

Exploring how space, time, and sampling impact our ability to measure genetic structure across Plasmodium falciparum populations

R Arambepola, S Bérubé, B Freedman… - Frontiers in …, 2023 - frontiersin.org
A primary use of malaria parasite genomics is identifying highly related infections to quantify
epidemiological, spatial, or temporal factors associated with patterns of transmission. For …

[HTML][HTML] Genetic diversity and population structure of Plasmodium falciparum in Lake Victoria Islands, a region of intense transmission

FM Mulenge, CW Hunja, E Magiri… - The American Journal …, 2016 - ncbi.nlm.nih.gov
Understanding the genetic structure and transmission dynamics of Plasmodium falciparum
parasites in malaria-endemic regions is crucial before the implementation of interventions …

Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution

CW Duffy, H Ba, S Assefa, AD Ahouidi… - Molecular …, 2017 - Wiley Online Library
To determine whether the major human malaria parasite Plasmodium falciparum exhibits
fragmented population structure or local adaptation at the northern limit of its African …

Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya

A Osborne, E Manko, M Takeda, A Kaneko… - Scientific Reports, 2021 - nature.com
Characterising the genomic variation and population dynamics of Plasmodium falciparum
parasites in high transmission regions of Sub-Saharan Africa is crucial to the long-term …

Investigating the drivers of the spatio-temporal patterns of genetic differences between Plasmodium falciparum malaria infections in Kilifi County, Kenya

J Malinga, P Mogeni, I Omedo, K Rockett, C Hubbart… - Scientific reports, 2019 - nature.com
Abstract Knowledge of how malaria infections spread locally is important both for the design
of targeted interventions aiming to interrupt malaria transmission and the design of trials to …

High genetic complexity but low relatedness in Plasmodium falciparum infections from Western Savannah Highlands and coastal equatorial Lowlands of Cameroon

NI Atuh, DN Anong, FC Jerome, E Oriero… - Pathogens and global …, 2022 - Taylor & Francis
To determine the diversity and connectivity of infections in Northwestern and Southwestern
Cameroon, 232 Plasmodium falciparum infections, collected in 2018 from the Ndop Health …