Microsatellite repeat DNA is best known for its length mutability, which is implicated in
several neurological diseases and cancers, and often exploited as a genetic marker. Less …

Microsatellites are among the most versatile of genetic markers, being used in an impressive
number of biological applications. However, the evolutionary dynamics of these markers …

Recently, increasingly more microsatellites, or simple sequence repeats (SSRs) have been
found and characterized within protein-coding genes and their untranslated regions (UTRs) …

Mutation rates of microsatellites vary greatly among loci. The causes of this heterogeneity
remain largely enigmatic yet are crucial for understanding numerous human neurological …

Rapid advances in DNA sequencing and genotyping technologies are beginning to reveal
the scope and pattern of human genomic variation. Although single nucleotide …

Ahuman's genetic code consists of roughly three billion bases of DNA, the familiar “letters” of
the DNA al-phabet. But a mere 10 to 15 percent of those bases make up genes, the …

Tandem repeats are genomic elements that are prone to changes in repeat number and are
thus often polymorphic. These sequences are found at a high density at the start of human …

Microsatellite sequences are ubiquitous in the human genome and are important regulators
of genome function. Here, we examine the mutational mechanisms governing the stability of …

Microsatellites are abundant in vertebrate genomes, but their sequence representation and
length distributions vary greatly within each family of repeats (eg, tetranucleotides) …

Background Microsatellite loci are frequently used in genomic studies of DNA sequence
repeats and in population studies of genetic variability. To investigate the effect of sequence …