Attenuated replication and pathogenicity of SARS-CoV-2 B. 1.1. 529 Omicron

H Shuai, JFW Chan, B Hu, Y Chai, TTT Yuen, F Yin… - Nature, 2022 - nature.com
Abstract The Omicron (B. 1.1. 529) variant of SARS-CoV-2 emerged in November 2021 and
is rapidly spreading among the human population. Although recent reports reveal that the …

[PDF][PDF] Reduced pathogenicity of the SARS-CoV-2 omicron variant in hamsters

K McMahan, V Giffin, LH Tostanoski, B Chung… - Med, 2022 - cell.com
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
(B. 1.1. 529) variant has proven to be highly transmissible and has outcompeted the Delta …

SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo

KPY Hui, JCW Ho, M Cheung, K Ng, RHH Ching, K Lai… - Nature, 2022 - nature.com
The emergence of SARS-CoV-2 variants of concern with progressively increased
transmissibility between humans is a threat to global public health. The Omicron variant of …

SARS-CoV-2 Omicron efficiently infects human airway, but not alveolar epithelium

MM Lamers, AZ Mykytyn, TI Breugem, N Groen… - BioRxiv, 2022 - biorxiv.org
In late 2021, the highly mutated SARS-CoV-2 Omicron variant emerged, raising concerns
about its potential extensive immune evasion, increased transmissibility and pathogenicity …

SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance

X Zhang, S Wu, B Wu, Q Yang, A Chen, Y Li… - Signal transduction and …, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron strain (as known
as B. 1.1. 529) was identified in Botswana and South Africa in early November 2021 and …

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

B Meng, A Abdullahi, IATM Ferreira, N Goonawardane… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in 2021 and has multiple
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …

Clinical outcomes associated with SARS-CoV-2 Omicron (B. 1.1. 529) variant and BA. 1/BA. 1.1 or BA. 2 subvariant infection in Southern California

JA Lewnard, VX Hong, MM Patel, R Kahn, M Lipsitch… - Nature medicine, 2022 - nature.com
Epidemiologic surveillance has revealed decoupling of Coronavirus Disease 2019 (COVID-
19) hospitalizations and deaths from case counts after emergence of the Omicron (B. 1.1 …

Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters

S Yuan, ZW Ye, R Liang, K Tang, AJ Zhang, G Lu… - Science, 2022 - science.org
The in vivo pathogenicity, transmissibility, and fitness of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) Omicron (B. 1.1. 529) variant are not well …

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

R Suzuki, D Yamasoba, I Kimura, L Wang, M Kishimoto… - Nature, 2022 - nature.com
The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern. In
this study, our statistical modelling suggests that Omicron has spread more rapidly than the …

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

PJ Halfmann, S Iida, K Iwatsuki-Horimoto, T Maemura… - Nature, 2022 - nature.com
The recent emergence of B. 1.1. 529, the Omicron variant,, has raised concerns of escape
from protection by vaccines and therapeutic antibodies. A key test for potential …