Le récepteur Fas (CD95) et son ligand FasL (CD95-L) jouent un rôle clé dans la mort des
lymphocytes T. Alors que la caspase-8 a été montrée comme essentielle dans l'apoptose …

La voie apoptotique induite par le récepteur Fas et son ligand (FasL) est impliquée dans de
nombreux mécanismes physiologiques et pathologiques. Cette voie se décompose en deux …

Engagement of the Fas receptor promotes apoptosis by activation of caspases. In addition,
alterations in plasma membrane lipid orientation and intracellular ceramide levels are often …

The Fas receptor is one of a number of important physiological inducers of programmed cell
death (apoptosis). Current models for regulation of this process involve rapid conversion of …

Background An unregulated process of lymphocyte apoptosis, which involves cells
irrespective of whether they are bearing the human immunodeficiency virus (HIV) genome …

Since its discovery, caspase-8 has been placed at the apex of the proteolytic cascade
triggered by death receptor (DR) cross-linking. Because of its capacity to interact with the …

Résumé The receptor Fas/CD95 can trigger cell death if activated by its ligand, FasL. In
addition, Fas can mediate proliferation and differentiation. An imbalance between these life …

Abstract Fas ligand (FasL, CD95L) is the key death factor of receptor‐triggered programmed
cell death in immune cells. FasL/Fas‐dependent apoptosis plays a pivotal role in activation …

Triggering of Fas (CD95) by its ligand (FasL) rapidly induces cell death via recruitment of the
adaptor protein Fas-associated death domain (FADD), resulting in activation of a caspase …

Fas triggers apoptosis via the caspase cascade when bound to its ligand FasL. In type I
cells, Fas is concentrated into the plasma membrane lipid rafts, and these domains are …