Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, but at high dose it
leads to undesirable side effects, such as hepatotoxicity and nephrotoxicity. The present …

High or toxic doses of acetaminophen (APAP), a mild analgesic and antipyretic drug, can
cause life-threatening hepatic and renal dysfunction. This study is designed to investigate …

Context: Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known
agent to cause hepatic and renal toxicity at a higher dose. Naringin, a bioflavonoid …

Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …

Context: Acetaminophen (APAP) leads to severe hepatic and renal necrosis and thus
causes significant clinical problems. Artemisia pallens Walls ex DC (Asteraceae) possesses …

The most important reason for the non-approval and withdrawal of drugs by the Food and
Drug Administration is hepatotoxicity. Therefore, this study was undertaken to evaluate the …

Cinnamomum zeylanicum, a widely used spice and flavor, is used in the treatment and
prevention of many diseases. In the current study, Balb/c mice were pretreated with …

Paracetamol (acetaminophen, PCM) is widely used as an over-the-counter analgesic and
antipyretic drug. Intake of a large dose of PCM may result in severe hepatic necrosis …

Experimental study was conducted to evaluate the hepato-and renoprotective effect of
silymarin and Terminalia chebula against experimentally-induced acetaminophen (APAP) …

This study investigated the possible protective effects and mechanism of rhein on
Acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity in rats. Treatment of rats …