Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, but at high dose it
leads to undesirable side effects, such as hepatotoxicity and nephrotoxicity. The present …
leads to undesirable side effects, such as hepatotoxicity and nephrotoxicity. The present …
Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species
MM El-Shafey, GM Abd-Allah, AM Mohamadin… - Pathophysiology, 2015 - Elsevier
High or toxic doses of acetaminophen (APAP), a mild analgesic and antipyretic drug, can
cause life-threatening hepatic and renal dysfunction. This study is designed to investigate …
cause life-threatening hepatic and renal dysfunction. This study is designed to investigate …
Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1
M Adil, AD Kandhare, P Ghosh, S Venkata… - Renal failure, 2016 - Taylor & Francis
Context: Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known
agent to cause hepatic and renal toxicity at a higher dose. Naringin, a bioflavonoid …
agent to cause hepatic and renal toxicity at a higher dose. Naringin, a bioflavonoid …
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via …
J Wan, G Kuang, L Zhang, R Jiang, Y Chen… - International …, 2020 - Elsevier
Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …
Artemisia pallens alleviates acetaminophen induced toxicity via modulation of endogenous biomarkers
Context: Acetaminophen (APAP) leads to severe hepatic and renal necrosis and thus
causes significant clinical problems. Artemisia pallens Walls ex DC (Asteraceae) possesses …
causes significant clinical problems. Artemisia pallens Walls ex DC (Asteraceae) possesses …
Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammation
AM Mahmoud - Canadian journal of physiology and …, 2014 - cdnsciencepub.com
The most important reason for the non-approval and withdrawal of drugs by the Food and
Drug Administration is hepatotoxicity. Therefore, this study was undertaken to evaluate the …
Drug Administration is hepatotoxicity. Therefore, this study was undertaken to evaluate the …
[HTML][HTML] Protective effects of Cinnamomum zeylanicum L.(Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model
Cinnamomum zeylanicum, a widely used spice and flavor, is used in the treatment and
prevention of many diseases. In the current study, Balb/c mice were pretreated with …
prevention of many diseases. In the current study, Balb/c mice were pretreated with …
Acetaminophen-induced liver damage in mice: effects of some medicinal plants on the oxidative defense system
MT Olaleye, BTJ Rocha - Experimental and Toxicologic Pathology, 2008 - Elsevier
Paracetamol (acetaminophen, PCM) is widely used as an over-the-counter analgesic and
antipyretic drug. Intake of a large dose of PCM may result in severe hepatic necrosis …
antipyretic drug. Intake of a large dose of PCM may result in severe hepatic necrosis …
[HTML][HTML] Acetaminophen-induced Hepato-and Nephrotoxicity and Amelioration by Silymarin and Terminalia chebula in Rats
KS Gopi, AG Reddy, K Jyothi, BA Kumar - Toxicology international, 2010 - ncbi.nlm.nih.gov
Experimental study was conducted to evaluate the hepato-and renoprotective effect of
silymarin and Terminalia chebula against experimentally-induced acetaminophen (APAP) …
silymarin and Terminalia chebula against experimentally-induced acetaminophen (APAP) …
Rhein protects against acetaminophen-induced hepatic and renal toxicity
YL Zhao, GD Zhou, HB Yang, JB Wang… - Food and chemical …, 2011 - Elsevier
This study investigated the possible protective effects and mechanism of rhein on
Acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity in rats. Treatment of rats …
Acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity in rats. Treatment of rats …
相关搜索
- oxidative stress wistar rats
- oxidative stress protective effects
- laboratory rats renal toxicity
- oxidative stress hepatotoxicity by upregulation
- induced toxicity endogenous biomarkers
- induced toxicity artemisia pallens
- oxidative stress hepatocyte necrosis
- oxidative stress inflammatory response
- oxidative stress upregulation of pparγ