Controlling the access of proteases to cleavable peptides placed at specific locations within
macromolecular architectures represents a powerful strategy for biologically responsive …

We describe a strategy for rendering peptides resistant to proteolysis by formulating them as
high-density brush polymers. The utility of this approach is demonstrated by polymerizing …

Cellular uptake by macrophages and ensuing clearance by the mononuclear phagocyte
system stands as a significant biological barrier for nanoparticle therapeutics. While there is …

Peptide-brush polymers (PBPs), wherein every side-chain of the polymers is peptidic,
represent a new class of proteomimetic with unusually high proteolytic resistance while …

Bottlebrush copolymers with different chemical structures and compositions as well as
diverse architectures represent an important kind of material for various applications, such …

Bottlebrush polymers, macromolecules consisting of dense polymer side chains grafted from
a central polymer backbone, have unique properties resulting from this well-defined …

Harnessing metal‐free photoinduced reversible‐deactivation radical polymerization (photo‐
RDRP) in organic and aqueous phases, we report a synthetic approach to enzyme …

Protease–protease interactions lie at the heart of the biological cascades that provide rapid
molecular responses to living systems. Blood clotting cascades, apoptosis signaling …

Molecular bottlebrushes featuring brush-on-brush (BoB) architecture were prepared by
combining azide–alkyne click chemistry, ring-opening polymerization (ROP), and atom …

Recently, we presented a strategy for packaging peptides as side‐chains in high‐density
brush polymers. For this globular protein‐like polymer (PLP) formulation, therapeutic …