We have explored the functional implications of inducible α4 integrin deletion during adult
hematopoiesis by generating a conditional-knockout mouse model, and we show that α4 …

Alpha4 integrin or VLA4 (CD49d/CD29) is a multitask molecule with wide expression within
and outside the hematopoietic system. Because targeted ablation of α4 integrin leads to …

We investigated roles of α4 integrins during hematopoiesis using mutant and chimeric mice.
Yolk sac erythropoiesis and migration of hematopoietic progenitors to fetal liver, spleen, and …

Antagonists to α4 integrin show promise for several autoimmune and inflammatory diseases
but may exhibit mechanism-based toxicities. We tested the capacity of blockade of α4 …

Self-renewing, multipotent hematopoietic stem cells are highly enriched within the Lin−
Thy1. 1loc-kit+ Sca-1+ subset of mouse bone marrow. However, heterogeneous expression …

Mice chimeric for the expression of α4 integrins were used to dissect the roles of these
receptors in development and traffic of lymphoid and myeloid cells. During fetal life, T cell …

The laminin receptor integrin α6 chain is ubiquitously expressed in human and mouse
hematopoietic stem and progenitor cells. We have studied its role for homing of stem and …

Mice chimeric for integrins α 5, α V, or α 4 were used to dissect the in vivo roles of these
adhesion receptors during leukocyte development and traffic. No major defects were …

The hierarchy of cytoadhesion molecules involved in hematopoietic/stem progenitor cell
mobilization has not yet been delineated. Previous studies have suggested an important …

The α2β1 integrin is a collagen/laminin receptor expressed on platelets, endothelial cells,
fibroblasts, and epithelial cells. To define the role of the α2β1 integrin in vivo, we created a …