Biofilm aggregates and the host airway-microbial interface

L Hall-Stoodley, KS McCoy - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Biofilms are multicellular microbial aggregates that can be associated with host mucosal
epithelia in the airway, gut, and genitourinary tract. The host environment plays a critical role …

Microbial biofilms in pulmonary and critical care diseases

AA Boisvert, MP Cheng, DC Sheppard… - Annals of the American …, 2016 - atsjournals.org
Microbial biofilms can colonize medical devices and human tissues, and their role in
microbial pathogenesis is now well established. Not only are biofilms ubiquitous in natural …

Airway biofilms: implications for pathogenesis and therapy of respiratory tract infections

H Kobayashi - Treatments in respiratory medicine, 2005 - Springer
The differentiation of bacterial biofilms in the airway environment, the pathogenesis of
airway biofilm, and possible therapeutic methods are discussed. Biofilm diseases that …

Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway

S Moreau-Marquis, BA Stanton, GA O'Toole - Pulmonary pharmacology & …, 2008 - Elsevier
The cystic fibrosis (CF) lung is chronically inflamed and infected by Pseudomonas
aeruginosa, which is a major cause of morbidity and mortality in this genetic disease …

Matrix exopolysaccharides; the sticky side of biofilm formation

E Maunders, M Welch - FEMS microbiology letters, 2017 - academic.oup.com
Abstract The Gram-negative pathogen Pseudomonas aeruginosa is found ubiquitously
within the environment and is recognised as an opportunistic human pathogen that …

Pattern differentiation in co-culture biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa

L Yang, Y Liu, T Markussen, N Høiby… - FEMS immunology & …, 2011 - academic.oup.com
Biofilm infections may not simply be the result of colonization by one bacterium, but rather
the consequence of pathogenic contributions from several bacteria. Interspecies interactions …

Approaches to targeting bacterial biofilms in cystic fibrosis airways

I Martin, V Waters, H Grasemann - International Journal of Molecular …, 2021 - mdpi.com
The treatment of lung infection in the context of cystic fibrosis (CF) is limited by a biofilm
mode of growth of pathogenic organisms. When compared to planktonically grown bacteria …

Bacterial biofilm in upper respiratory tract infections

DP Morris - Current Infectious Disease Reports, 2007 - Springer
The upper respiratory tract is of easy access to pathogens, and although it has evolved a
number of defensive barriers to avoid invasion, acute and chronic infections of the ears …

Pathogenesis of mucosal biofilm infections: challenges and progress

A Dongari-Bagtzoglou - Expert review of anti-infective therapy, 2008 - Taylor & Francis
Living-tissue biofilms remained unrecognized until very recently, mainly as a result of
traditional microbial sampling techniques or histologic processing, which disrupt the spatial …

[HTML][HTML] Host responses to mucosal biofilms in the lung and gut

JC Domingue, JL Drewes, CA Merlo, F Housseau… - Mucosal …, 2020 - Elsevier
The impact of the human microbiome on health and disease is of utmost importance and has
been studied intensively in recent years. Microbes promote immune system development …