[HTML][HTML] Sleep-promoting activity of amylase-treated Ashwagandha (Withania somnifera L. Dunal) root extract via GABA receptors

CW Park, KB Hong, HJ Suh, Y Ahn - Journal of Food and Drug …, 2023 - ncbi.nlm.nih.gov
Abstract Ashwagandha (Withania somnifera L. Dunal), an Indian medicinal plant that has
been used for centuries to treat insomnia, exhibits a variety of biological activities, such as …

[HTML][HTML] Hydroalcoholic extract of ashwagandha improves sleep by modulating GABA/histamine receptors and EEG slow-wave pattern in in vitro-in vivo experimental …

SV Murthy, SN Fathima, R Mote - Preventive Nutrition and Food …, 2022 - ncbi.nlm.nih.gov
Withania somnifera (ashwagandha) has been used traditionally as a remedy for insomnia
and to enhance cognitive function. The effects of ashwagandha extract (AE, 35 …

[HTML][HTML] Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction

MK Kaushik, SC Kaul, R Wadhwa, M Yanagisawa… - PloS one, 2017 - journals.plos.org
Insomnia is the most common sleep complaint which occurs due to difficulty in falling asleep
or maintaining it. Most of currently available drugs for insomnia develop dependency and/or …

Aqueous Leaf Extract of Withania somnifera as a Potential Neuroprotective Agent in Sleep-deprived Rats: a Mechanistic Study

S Manchanda, R Mishra, R Singh, T Kaur… - Molecular neurobiology, 2017 - Springer
Modern lifestyle and sustained stress of professional commitments in the current societal set
up often disrupts the normal sleep cycle and duration which is known to lead to cognitive …

Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized …

D Langade, V Thakare, S Kanchi, S Kelgane - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Ashwagandha (Withania somnifera (L.) Dunal.) is
long known for its sleep-inducing effects. Ashwagandha can be proposed as an alternative …

[HTML][HTML] Efficacy and safety of Ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study

D Langade, S Kanchi, J Salve, K Debnath… - Cureus, 2019 - ncbi.nlm.nih.gov
Objective To determine the efficacy and safety of Ashwagandha root extract in patients with
insomnia and anxiety. Methods This was a randomized, double-blind, placebo-controlled …

[HTML][HTML] Effect of Withania somnifera on sleep-wake cycle in sleep-disturbed rats: Possible GABAergic mechanism

A Kumar, H Kalonia - Indian journal of pharmaceutical sciences, 2008 - ncbi.nlm.nih.gov
Sleep deprivation disrupts significantly sleep pattern and cause poor quality of sleep. The
aim the present study was to explore role of Withania somniferra root extract in sleep …

A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults

A Deshpande, N Irani, R Balkrishnan, IR Benny - Sleep medicine, 2020 - Elsevier
Objective Non-restorative sleep (NRS) affects 10% people worldwide, leading to poor sleep
quality, as well as physical and cognitive fatigue. This is the first human study in which an …

[HTML][HTML] Treatment of GABA from fermented rice germ ameliorates caffeine-induced sleep disturbance in mice

DFN Mabunga, ELT Gonzales, HJ Kim… - Biomolecules & …, 2015 - ncbi.nlm.nih.gov
Abstract γ-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian
central nervous system, is involved in sleep physiology. Caffeine is widely used …

[HTML][HTML] Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis

KL Cheah, MN Norhayati, LH Yaacob, RA Rahman - PloS one, 2021 - journals.plos.org
Objective To determine the effect of Ashwagandha extract on sleep. Methods A
comprehensive search was conducted in CENTRAL, MEDLINE, SCOPUS, Google Scholars …