Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and
even disability. Although there are various clinical therapies for RA, some patients still have …

Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …

G protein-coupled receptors (GPCRs) are transmembrane receptor proteins that allow the
transfer of signals across the cell membrane. In addition to their physiological role, GPCRs …

Introduction G protein-coupled receptors (GPCRs) are transmembrane receptor proteins,
which allow the transfer of signals across the membrane. Rheumatoid arthritis (RA) is an …

The development of biological therapies has improved management of rheumatoid arthritis.
However, costs and unresponsiveness to therapy in a sizeable proportion of patients limit …

Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases and a
prototypic inflammatory disease, affecting the small joints of the hands and feet. Chemokines …

Advances in our understanding of the cellular and molecular mechanisms in rheumatic
disease fostered the advent of the targeted therapeutics era. Intense research activity …

Rheumatoid arthritis (RA) is a multisystemic and inflammatory autoimmune disease
characterized by joint destruction. The C–C motif chemokine receptor 2 (CCR2) is mainly …

G protein-coupled receptors (GPCRs) play important roles in human physiology. GPCRs are
involved in immunoregulation including regulation of the inflammatory response …

Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of
innate and adaptive immune systems-associated inflammatory responses. Due to the local …