Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

[HTML][HTML] Advances in neural stem cell therapy for spinal cord injury: safety, efficacy, and future perspectives

S Lee, H Nam, KM Joo, SH Lee - Neurospine, 2022 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) is a devastating central nervous system injury that leads to severe
disabilities in motor and sensory functions, causing significant deterioration in patients' …

Review of transplantation of neural stem/progenitor cells for spinal cord injury

AJ Mothe, CH Tator - International Journal of Developmental Neuroscience, 2013 - Elsevier
Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently
there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy …

Regenerative replacement of neural cells for treatment of spinal cord injury

WB McIntyre, K Pieczonka, M Khazaei… - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Introduction: Traumatic Spinal Cord Injury (SCI) results from primary physical
injury to the spinal cord, which initiates a secondary cascade of neural cell death. Current …

Improving the therapeutic efficacy of neural progenitor cell transplantation following spinal cord injury

MA Lane, AC Lepore, I Fischer - Expert review of neurotherapeutics, 2017 - Taylor & Francis
Introduction: There have been a wide range of preclinical studies testing cellular therapies to
repair the injured spinal cord, yet they remain a challenge to translate because of …

[HTML][HTML] Current concepts of neural stem/progenitor cell therapy for chronic spinal cord injury

H Suzuki, Y Imajo, M Funaba, N Nishida… - Frontiers in Cellular …, 2022 - frontiersin.org
Chronic spinal cord injury (SCI) is a devastating condition that results in major neurological
deficits and social burden. It continues to be managed symptomatically, and no real …

Neural stem cells for spinal cord repair

B Sandner, P Prang, FJ Rivera, L Aigner, A Blesch… - Cell and tissue …, 2012 - Springer
Spinal cord injury (SCI) causes the irreversible loss of spinal cord parenchyma including
astroglia, oligodendroglia and neurons. In particular, severe injuries can lead to an almost …

[HTML][HTML] A narrative review of advances in neural precursor cell transplantation therapies for spinal cord injury

T Kitagawa, N Nagoshi, H Okano, M Nakamura - Neurospine, 2022 - ncbi.nlm.nih.gov
A spinal cord injury (SCI) is a destructive event that causes a permanent deficit in
neurological function because of poor regenerative potential. Transplantation therapies …

Human spinal oligodendrogenic neural progenitor cells enhance pathophysiological outcomes and functional recovery in a clinically relevant cervical spinal cord …

K Pieczonka, H Nakashima, N Nagoshi… - Stem Cells …, 2023 - academic.oup.com
Traumatic spinal cord injury (SCI) results in the loss of neurons, oligodendrocytes, and
astrocytes. Present interventions for SCI include decompressive surgery, anti-inflammatory …

The application of neural stem/progenitor cells for regenerative therapy of spinal cord injury

C Yu, K Xia, Z Gong, L Ying, J Shu… - Current stem cell …, 2019 - ingentaconnect.com
Spinal cord injury (SCI) is a devastating event, and there are still no effective therapies
currently available. Neural stem cells (NSCs) have gained increasing attention as promising …