Tachykinins are important in the development of pulmonary inflammation in mice but the
tachykinin receptor subtype mediating this response has not been defined. To elucidate the …

BACKGROUND: Tachykinins are present in sensory nerves and in nonneuronal cells like
macrophages. Human data suggest a role for these peptides in asthma, but the exact role of …

Neurokinins (NKs), which include substance P (SP) and neurokinin A (NKA), act through NK-
1 and NK-2 receptors. There is considerable evidence of interaction between the …

Mast cell activation, bronchoconstriction, inflammation and airway hyperreactivity are
prominent features of non-atopic hypersensitivity reactions in mouse airways. We studied …

Using a guinea pig model of allergic asthma, we investigated the effects of the inhaled,
highly selective nonpeptide tachykinin NK1 and NK2 receptor antagonists SR 140333 and …

It has been suggested that tachykinin NK1 receptor-mediated neurogenic inflammation,
characterized by microvascular leakage, mucus secretion, and infiltration and activation of …

Several observations suggest that tachykinins (substance P, neurokinin A and neurokinin B)
are involved in the pathogenesis of pulmonary diseases and elicit several airway responses …

In this study, we investigated the involvement of neurokinin NK3 receptors in a severe
asthma model prepared by administering ovalbumin via inhalation three times to …

Rationale: The tachykinins substance P and neurokinin A (NKA) are implicated in the
pathophysiology of asthma. Objective: We tested the safety, tolerability, and pharmacologic …

Several observations suggest that tachykinins are involved in the pathogenesis of
bronchopulmonary alterations. We have investigated the effect of antagonists for tachykinin …