3-Aryl/hetaryl-2-cyanoacryloyl chlorides: Synthesis and reactions with binucleophiles targeting heterocycles

EAE El-Helw, AK El-Ziaty - Egyptian Journal of Chemistry, 2022 - journals.ekb.eg
In this review, we reported the synthetic method used to construct thirteen derivatives of 3-
aryl/heteryl-2-cyanoacryloyl chloride followed by a focused survey on their spectral data and …

o-Alkynylaryl 2-Cyanoacrylates: A Synthon for the Construction of Diverse Isoquinolones/Napthyridinones

Muskan, AK Verma - Organic Letters, 2024 - ACS Publications
o-Alkynylaryl 2-cyanoacrylates have been disclosed as a new synthon for the regioselective
synthesis of isoquinolones and naphthyridinones under mild reaction conditions. The …

An effective new access to ethyl 2-[(alkylamino)(cyano) methyl] acrylates: First synthesis of ethyl 3-cyano-2-(hydroxymethyl) acrylate

A Arfaoui, H Amri - Tetrahedron, 2009 - Elsevier
A regioselective coupling of ethyl 2-(bromomethyl)-3-cyanoacrylate and primary amines is
described to give ethyl 2-[(alkylamino)(cyano) methyl] acrylates in good yields. Whereas the …

Isocyanide-based multicomponent reactions: synthesis of 3, 3-dicyano-N-alkyl-2-arylpropanamide derivatives

E Soleimani, M Zainali, S Samadi - Tetrahedron letters, 2011 - Elsevier
A new isocyanide-based multicomponent reaction between an aromatic aldehyde,
malononitrile, an isocyanide, and acetic acid efficiently provides 3, 3-dicyano-N-alkyl-2 …

2-Cyano-N-(4-sulfamoylphenyl) Acetamide as a Synthon in Heterocyclic Synthesis

MA Gouda - Synthetic Communications, 2014 - Taylor & Francis
Full article: 2-Cyano-N-(4-sulfamoylphenyl) Acetamide as a Synthon in Heterocyclic Synthesis
Skip to Main Content Taylor and Francis Online homepage Taylor and Francis Online homepage …

Utility of 2-cyano-N-(2-hydroxyethyl) acetamide in heterocyclic synthesis

MA Gouda, MA Sabah, WK Aljuhani… - European Journal of …, 2015 - eurjchem.com
This review presents a systematic and comprehensive survey of the method of preparation
and the chemical reactivity of 2-cyano-N-(2-hydroxyethyl) acetamide. The target compounds …

Synthesis and X-ray Characterization of Alkali Metal 2-Acyl-1, 1, 3, 3-tetracyanopropenides

SV Karpov, AA Grigor'ev, YS Kayukov… - The Journal of …, 2016 - ACS Publications
A novel route for synthesis of 2-acyl-1, 1, 3, 3-tetracyanopropenides (ATCN) salts in high
yields and excellent purities starting from readily available methyl ketones, malononitrile …

Isocyanide-based multicomponent reactions in the synthesis of heterocycles

S Sadjadi, MM Heravi, N Nazari - RSC advances, 2016 - pubs.rsc.org
Isocyanide-based multicomponent reactions in the synthesis of heterocycles - RSC Advances
(RSC Publishing) DOI:10.1039/C6RA02143C Royal Society of Chemistry View PDF …

A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3, 4-dicarboxylates

R Mossetti, D Caprioglio, G Colombano… - Organic & …, 2011 - pubs.rsc.org
A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates
- Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C0OB00979B Royal …

Synthesis, biological evaluation and X-ray crystallographic analysis of novel (E)-2-cyano-3-(het) arylacrylamides as potential anticancer agents

C Serrano-Sterling, D Becerra, J Portilla… - Journal of Molecular …, 2021 - Elsevier
We report the stereoselective synthesis of novel (E)-2-cyano-3-(het) arylacrylamides 3 in
high yields by a triethylamine-catalyzed Knoevenagel condensation of cyanoacetamide (1) …