Increasing evidence has challenged the traditional view about the immune privilege of the
brain, but the precise roles of immune cells in regulating brain physiology and function …

Cognitive decline is a common pathological outcome during aging, with an ill‐defined
molecular and cellular basis. In recent years, the concept of inflammaging, defined as a low …

Recent research into meningeal lymphatics has revealed a never-before appreciated role of
type II innate lymphoid cells (ILC2s) in modulating neuroinflammation in the central nervous …

Brain aging often results in cognitive impairment and is considered to be a major risk factor
for neurodegenerative diseases. Earlier studies reported inflammatory responses in aged …

Microglia, the innate immune cells of the brain, develops a pro‐inflammatory,“primed” profile
with age. Using single‐cell RNA‐sequencing, we confirmed hippocampal microglia of aged …

The adaptive arm of the immune system has been suggested as an important factor in brain
function. However, given the fact that interactions of neurons or glial cells with T lymphocytes …

The effects of aging on innate immunity and the resulting impacts on immunosenescence
remain poorly understood. Here, we report that aging induces compartmentalized changes …

Excessive production of pro-inflammatory cytokines in the senescent brain in response to
peripheral immune stimulation is thought to induce behavioral pathology, however, few …

Background The immune cell compartment of the mammalian brain changes dramatically
and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the …

Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In
the aged brain, senescent cell identities and the mechanisms by which they exert adverse …