Developments in immunoassays and mass spectrometry have independently influenced
diagnostic technology. However, both techniques possess unique strengths and limitations …

Recent applications of affinity mass spectrometry into clinical laboratories brought a
renewed interest in immunoaffinity mass spectrometry as a more specific affinity method …

Immunoassays have made it possible to measure dozens of individual proteins and other
analytes in human samples for help in establishing the diagnosis and prognosis of disease …

The increase in the use of therapeutic monoclonal antibodies (mAbs) and antibody-drug
conjugates (ADCs) has made the detailed bioanalysis of these drugs essential not only for …

Therapeutic monoclonal antibodies (MAbs) are an important class of drugs used to treat
diseases ranging from autoimmune disorders to B cell lymphomas to other rare conditions …

Highlights•We describe the practical use of mass spectrometry for ADC characterization
including qualitative and quantitative analysis.•Technical advances, limitations and future …

Immunoassay is one of the most important clinical techniques for disease/pathological
diagnosis. Mass spectrometry (MS) has been a popular and powerful readout technique for …

Multispecific antibodies have gained significant importance in a broad indication space due
to their ability to engage multiple epitopes simultaneously and to thereby overcome …

The issue of how to rapidly identify and quantify multiple proteins of known structure in
biological samples is a subject of great interest today, particularly in the biomarker validation …

Although mass spectrometry has been used clinically for decades, the advent of
immunoassay technology moved the clinical laboratory to more labor saving automated …