Aquaporin-0 (AQP0) is a tetrameric membrane protein and the most abundant membrane
protein in the eye lens. Interestingly, there is little to no cellular turnover once mature lens …

Aquaporin-0 (AQP0), the major integral membrane protein in lens fiber cells, becomes
highly modified with increasing age. The functional consequences of these modifications are …

Purpose: To spatially map human lens Aquaporin-0 (AQP0) protein modifications, including
lipidation, truncation, and deamidation, from birth through middle age using matrix-assisted …

Because of the lack of protein turnover in fiber cells of the ocular lens, Aquaporin 0 (AQP0),
the most abundant membrane protein in the lens, undergoes extensive post-translational …

Fatty acid acylation of proteins is a well-studied co-or posttranslational modification typically
conferring membrane trafficking signals or membrane anchoring properties to proteins …

The human lens is ideal for the study of macromolecular aging because cells in the centre,
along with their constituent proteins, are present for our entire lives. We examined the major …

purpose. To first assess the distribution of posttranslationally truncated products of
aquaporin 0 (AQP0) in dissected sections of a normal human lens and to determine the …

purpose. Aquaporin 0 (AQP0), the most abundant membrane protein in the lens, is a water-
permeable channel, has a role in fiber cell adhesion, and is essential for fiber cell structure …

Due to hydrophobicity, structural analysis of integral membrane proteins poses a formidable
challenge for current mass spectrometry-based proteomics approaches. Herein, we …

In the human ocular lens it is now realized that post-translational modifications can alter
protein function and/or localization in fiber cells that no longer synthesize proteins. The …