Integrated biosensor for rapid and point-of-care sepsis diagnosis

J Min, M Nothing, B Coble, H Zheng, J Park, H Im… - Acs Nano, 2018 - ACS Publications
Sepsis is an often fatal condition that arises when the immune response to an infection
causes widespread systemic organ injury. A critical unmet need in combating sepsis is the …

[HTML][HTML] Nanoparticle-based mobile biosensors for the rapid detection of sepsis biomarkers in whole blood

A Alba-Patino, SM Russell, M Borges… - Nanoscale …, 2020 - pubs.rsc.org
Detecting small variations in the levels of IL-6 is crucial for the early diagnosis of sepsis. To
be useful in clinical decision-making, this requires detecting IL-6 rapidly in whole blood and …

Multiplexed cytokine detection using electrochemical point-of-care sensing device towards rapid sepsis endotyping

AS Tanak, S Muthukumar, S Krishnan… - Biosensors and …, 2021 - Elsevier
The implementation of endotype-driven effective intervention strategies is now considered
as an essential component for sepsis management. Rapid screening and frequent …

Rapid detection of sepsis: recent advances in biomarker sensing platforms

TJ Durkin, B Barua, S Savagatrup - ACS omega, 2021 - ACS Publications
Sepsis is a major cause of mortality among hospitalized patients worldwide. Rapid
diagnosis is critical as early treatments have been demonstrated to improve survival …

[HTML][HTML] Micro-and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care

A Alba-Patiño, A Vaquer, E Barón, SM Russell… - Microchimica Acta, 2022 - Springer
Severe infections can cause a dysregulated response leading to organ dysfunction known
as sepsis. Sepsis can be lethal if not identified and treated right away. This requires …

[HTML][HTML] Development of a needle shaped microelectrode for electrochemical detection of the sepsis biomarker interleukin-6 (IL-6) in real time

C Russell, AC Ward, V Vezza, P Hoskisson… - Biosensors and …, 2019 - Elsevier
This paper outlines a simple label-free sensor system for the sensitive, real time
measurement of an important protein biomarker of sepsis, using a novel microelectrode …

Recent advances in biosensors for diagnosis and detection of sepsis: A comprehensive review

S Kumar, S Tripathy, A Jyoti, SG Singh - Biosensors and Bioelectronics, 2019 - Elsevier
Sepsis is one of the leading causes of mortality among critically ill patients globally.
According to WHO report 2018, it is estimated to affect beyond 30 million people worldwide …

[HTML][HTML] Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology

A Pant, I Mackraj, T Govender - Journal of Biomedical Science, 2021 - Springer
Sepsis, a dysregulated immune response due to life-threatening organ dysfunction, caused
by drug-resistant pathogens, is a major global health threat contributing to high disease …

Toward the rapid diagnosis of sepsis: detecting interleukin-6 in blood plasma using functionalized screen-printed electrodes with a thermal detection methodology

RD Crapnell, W Jesadabundit… - Analytical …, 2021 - ACS Publications
This paper reports the detection of the inflammatory and sepsis-related biomarker,
interleukin-6 (IL-6), in human blood plasma using functionalized screen-printed electrodes …

[HTML][HTML] Point-of-care diagnostics for sepsis using clinical biomarkers and microfluidic technology

Z Bradley, N Bhalla - Biosensors and Bioelectronics, 2023 - Elsevier
Sepsis is a life-threatening immune response which is caused by a wide variety of sources
and is a leading cause of mortality globally. Rapid diagnosis and appropriate antibiotic …