Rapid phagocytosis of apoptotic cells is thought to limit the development of inflammation and
autoimmune disease. Serum enhances macrophage phagocytosis of apoptotic cells. Here …

The phagocytosis of apoptotic cells is a complex process involving numerous interactions
between the target cell and the macrophage. We have examined a role of the major soluble …

Prompt phagocytosis of apoptotic cells prevents inflammatory and autoimmune responses to
dying cells. We have previously shown that the blood anticoagulant factor protein S …

Apoptosis is characterized by a lack of inflammatory reaction in surrounding tissues,
suggesting local control of complement activation. During the initial stage of apoptosis, cells …

Protein S (PS) has an established role as an important cofactor to activated protein C (APC)
in the degradation of coagulation cofactors Va and VIIIa. This anticoagulant role is evident …

During resolution of an inflammatory response, recruited neutrophil granulocytes undergo
apoptosis and are removed by tissue phagocytes before induction of secondary necrosis …

S-protein, the main inhibitor of the assembly of the membrane attack complex of
complement, was isolated from human plasma by a simple purification procedure, which …

After cell death, via apoptosis or necrosis, the uptake of dead cells by neighboring cells or
phagocytes prevents the release of intracellular content. An array of molecules, including …

When cells undergo apoptosis, or programmed cell death, they expose phosphatidylserine
(PS) on their surface. Macrophages that efficiently phagocytose apoptotic cells also express …

Protein S deficiency is a known risk factor for thrombosis. The coexistence of phenotypic
type I (reduction in total and free antigen) and type III (reduction in free antigen only) protein …