Cisplatin, carboplatin, and oxaliplatin anticancer drugs are commonly used to treat lung,
colorectal, ovarian, breast, head and neck, and genitourinary cancers. However, the efficacy …

Neurotoxicity is a burdensome side effect of platinum-based chemotherapy that prevents
administration of the full efficacious dosage and often leads to treatment withdrawal …

Effective administration of traditional cytotoxic chemotherapy is often limited by off-target
toxicities. This clinical dilemma is epitomized by cisplatin, a platinating agent, which has …

Peripheral neurotoxicity is one of the most distressing side effects of oxaliplatin therapy for
cancer. Indeed, most patients that received oxaliplatin experience acute and/or chronic …

Cisplatin, a platinating agent commonly used to treat several cancers, is associated with
nephrotoxicity, neurotoxicity, and ototoxicity, which has hindered its utility. To gain a better …

Background Chemotherapy-induced peripheral neuropathy (CIPN) is regarded as one of the
most common dose-limiting adverse effects of several chemotherapeutic agents, such as …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating
condition associated with a number of chemotherapeutic agents. Drugs commonly …

BACKGROUND: To identify potential genetic markers for severe oxaliplatin‐induced chronic
peripheral neuropathy (OXCPN), the authors performed a genome‐wide association …

Oxaliplatin is a relatively new platinum analogue that is currently used in pharmacotherapy
of metastatic colorectal cancer. Its dose-limiting toxicity is sensory neuropathy, which can be …

NSCLC is the leading cause of cancer-related death in the US. Patients with NSCLC are
mostly treated with platinum-based chemotherapy, often in combination with radiation …