A new frontier in temporomandibular joint osteoarthritis treatment: Exosome-based therapeutic strategy

W Yuan, Y Wu, M Huang, X Zhou, J Liu, Y Yi… - … in Bioengineering and …, 2022 - frontiersin.org
Temporomandibular joint osteoarthritis (TMJOA) is a debilitating degenerative disease with
high incidence, deteriorating quality of patient life. Currently, due to ambiguous etiology, the …

Emerging potential of exosomes in regenerative medicine for temporomandibular joint osteoarthritis

YH Lee, HK Park, QS Auh, H Nah, JS Lee… - International journal of …, 2020 - mdpi.com
Exosomes are nanosized vesicles (30–140 nm) of endocytic origin that play important roles
in regenerative medicine. They are derived from cell membranes during endocytic …

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

S Zhang, KYW Teo, SJ Chuah, RC Lai, SK Lim… - Biomaterials, 2019 - Elsevier
The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to
paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC …

Exosomes of stem cells from human exfoliated deciduous teeth as an anti-inflammatory agent in temporomandibular joint chondrocytes via miR-100-5p/mTOR

P Luo, C Jiang, P Ji, M Wang, J Xu - Stem Cell Research & Therapy, 2019 - Springer
Objectives Temporomandibular joint osteoarthritis (TMJOA) is an inflammatory joint disease.
This study investigated whether exosomes (Exos) of stem cells from human exfoliated …

Exosomes derived from MSC as drug system in osteoarthritis therapy

S Wen, X Huang, J Ma, G Zhao, T Ma… - … in Bioengineering and …, 2024 - frontiersin.org
Osteoarthritis (OA) is the most common degenerative disease of the joint with irreversible
cartilage damage as the main pathological feature. With the development of regenerative …

Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis

H Yu, Y Huang, L Yang - Ageing research reviews, 2022 - Elsevier
Osteoarthritis (OA), as a common orthopedic disease with cartilage injury as its main
pathological feature, has a complex pathogenesis and existing medical technology remains …

Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis

D Luo, H Zhu, S Li, Z Wang, J Xiao - Frontiers in Bioengineering and …, 2024 - frontiersin.org
Osteoarthritis (OA), as a degenerative disease, leads to high socioeconomic burdens and
disability rates. The knee joint is typically the most affected and is characterized by …

Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis

Z Zhang, S Zhao, Z Sun, C Zhai, J Xia, C Wen… - Cellular & Molecular …, 2023 - Springer
Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main
pathological change, is the major source of pain and disability worldwide. Despite current …

The role and therapeutic potential of MSC-derived exosomes in osteoarthritis

C Bao, C He - Archives of Biochemistry and Biophysics, 2021 - Elsevier
Osteoarthritis (OA) is the most common painful disease with chronic articular cartilage
degeneration. The pathological process of OA is complex and characterized by the …

Engineering of MSC-derived exosomes: a promising cell-free therapy for osteoarthritis

J Cheng, Y Sun, Y Ma, Y Ao, X Hu, Q Meng - Membranes, 2022 - mdpi.com
Osteoarthritis (OA) is characterized by progressive cartilage degeneration with increasing
prevalence and unsatisfactory treatment efficacy. Exosomes derived from mesenchymal …