Abnormal enzymatic activities are directly related to the development of cancers. Identifying
the location and expression levels of these enzymes in live cancer cells have considerable …

Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

In cancer surgery, complete surgical resection of tumor lesions is critical to optimize the
outcome. However, it is sometimes difficult to distinguish the boundary between tumor and …

Conspectus Enzymes are a class of important substances for life, and their abnormal levels
are associated with many diseases. Thus, great progress has been made in the past decade …

Conventional imaging methods, such as angiography, computed tomography (CT),
magnetic resonance imaging (MRI), and radionuclide imaging, rely on contrast agents …

The real-time, dynamic optical visualization of lesions and margins ensures not only
complete resection of the malignant tissues but also better preservation of the vital …

The Precision Medicine Initiative aims to use advances in basic and clinical research to
develop therapeutics that selectively target and kill cancer cells. Under the same doctrine of …

Fluorogenic probes, small-molecule sensors that unmask brilliant fluorescence upon
exposure to specific stimuli, are powerful tools for chemical biology. Those probes that …

Fluorescent probes that can selectively detect tumour lesions have great potential for
fluorescence imaging-guided surgery. Here, we established a library-based approach for …

Small molecule fluorophores are essential tools for chemical biology. A benefit of synthetic
dyes is the ability to employ chemical approaches to control the properties and direct the …