Synthesis of new halogenated flavonoid-based isoxazoles: in vitro and in silico evaluation of a-amylase inhibitory potential, a SAR analysis and DFT studies
I Saidi, M Manachou, M Znati, J Bouajila… - Journal of Molecular …, 2022 - Elsevier
Carbohydrates are the main source of calories in most diets, and α-amylase is considered
one of the main enzymes that initiate their digestion. The inhibition of α-amylase is therefore …
one of the main enzymes that initiate their digestion. The inhibition of α-amylase is therefore …
Synthesis, crystal structures, computational studies and α-amylase inhibition of three novel 1, 3, 4-oxadiazole derivatives
Oxadiazoles have broad range of biological applications and have been investigated widely
by the scientific community. In this study, we report the synthesis, X-ray diffraction, density …
by the scientific community. In this study, we report the synthesis, X-ray diffraction, density …
[HTML][HTML] Trifluoromethylated Flavonoid-Based Isoxazoles as Antidiabetic and Anti-Obesity Agents: Synthesis, In Vitro α-Amylase Inhibitory Activity, Molecular Docking …
Diabetes mellitus is a major health problem globally. The management of carbohydrate
digestion provides an alternative treatment. Flavonoids constitute the largest group of …
digestion provides an alternative treatment. Flavonoids constitute the largest group of …
Triazole based novel molecules as potential therapeutic agents: Synthesis, characterization, biological evaluation, in-silico ADME profiling and molecular docking …
In this study, eight new compounds (7a-h) based on triazole compounds containing ester
groups were synthesized with high yields. The structures of the synthesized compounds (7a …
groups were synthesized with high yields. The structures of the synthesized compounds (7a …
Synthesis, in vitro α-amylase activity and molecular docking study of benzoxazole derivatives
In current study, an efficient and simple synthesis of phenyl-benzoxazoles derivatives (1–14)
were carried out, upon cyclization of 2-aminophenol with substituted aldehyde. All …
were carried out, upon cyclization of 2-aminophenol with substituted aldehyde. All …
Design and synthesis of 1, 4-disubstituted 1, 2, 3-triazoles: Biological evaluation, in silico molecular docking and ADME screening
In this study, propargyl compounds were synthesized from 4-hydroxybenzaldehyde and 3‑
methoxy-4-hydroxybenzaldehyde (2a-2b). As a result of click reactions of synthesized …
methoxy-4-hydroxybenzaldehyde (2a-2b). As a result of click reactions of synthesized …
In vitro and in silico studies of fluorinated 2, 3‐disubstituted thiazolidinone‐pyrazoles as potential α‐amylase inhibitors and antioxidant agents
As part of our effort to identify potent α‐amylase inhibitors, in the present study, a novel
series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the …
series of fluorinated thiazolidinone‐pyrazole hybrid molecules were prepared by the …
Synthesis, α-amylase inhibitory activity and molecular docking studies of 2, 4-thiazolidinedione derivatives
F Naeem, H Nadeem, A Muhammad… - Open Chemistry …, 2018 - benthamopen.com
Methods: All the synthesized compounds were characterized by elemental analysis, FTIR, 1
HNMR, and 13 CNMR and further screened for their α-amylase inhibitory potential. Results …
HNMR, and 13 CNMR and further screened for their α-amylase inhibitory potential. Results …
Discovery of new 1,4-disubstituted 1,2,3-triazoles: in silico ADME profiling, molecular docking and biological evaluation studies
In this work, eight new 1, 2, 3-triazoles (6a–h) were synthesized from acetylenes'“click”
reaction with p-substituted azide derivatives. The structures of the compounds were …
reaction with p-substituted azide derivatives. The structures of the compounds were …
Synthesis, α-amylase and α-glucosidase inhibition and molecular docking studies of indazole derivatives
Herein, we report the synthesis and inhibitory potential of indazole (Methyl 1 H-indazole-4-
carboxylate) derivatives (1–13) against α-amylase and α-glucosidase enzymes. The …
carboxylate) derivatives (1–13) against α-amylase and α-glucosidase enzymes. The …