Metabolic heterogeneity between neoplastic cells and surrounding stroma has been
described in several epithelial malignancies; however, the metabolic phenotypes of …

Purpose Increased glycolytic activity with accumulation of extracellular lactate is regarded as
a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic …

Background Twenty percent of patients with classical Hodgkin Lymphoma (cHL) have
aggressive disease defined as relapsed or refractory disease to initial therapy. At present we …

Background We evaluated the therapeutic potential of combining the monocarboxylate
transporter 1 (MCT1) inhibitor AZD3965 with the mitochondrial respiratory Complex I …

Recently, we proposed a new mechanism for understanding the Warburg effect in cancer
metabolism. In this new paradigm, cancer-associated fibroblasts undergo aerobic glycolysis …

Tumors frequently display a glycolytic phenotype with increased flux through glycolysis and
concomitant synthesis of lactate. To maintain glycolytic flux and prevent intracellular …

Epstein–Barr virus (EBV) is a ubiquitous herpesvirus that typically causes asymptomatic
infection but can promote B lymphoid tumors in the immune suppressed. In vitro, EBV …

The fate of pyruvate is a defining feature in many cell types. One major fate is mitochondrial
entry via the mitochondrial pyruvate carrier (MPC). We found that diffuse large B cell …

Myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehydrogenase-
A that generates lactate. Here, we report that Myc controls transcription of the lactate …

Cancer metabolic reprogramming has been recognized as one of the cancer hallmarks that
promote cell proliferation, survival, as well as therapeutic resistance. Up-to-date regulation …