Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

The locus coeruleus (LC), the major origin of noradrenergic modulation of the central
nervous system, innervates extensive areas throughout the brain and is implicated in a …

Noradrenergic dysfunction contributes to cognitive impairment in Alzheimer's Disease (AD)
and Parkinson's Disease (PD). Conventional therapeutic strategies seek to enhance …

The locus coeruleus (LC) noradrenergic system regulates arousal and modulates attention
through its extensive projections across the brain. LC dysfunction has been implicated in a …

The locus coeruleus (LC) has long been underappreciated for its role in the pathophysiology
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …

The locus coeruleus (LC), a major origin of noradrenergic projections in the central nervous
system (CNS), may serve a critical role in the pathogenesis of neurodegenerative disorders …

Previous studies have reported substantial involvement of the noradrenergic system in
Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become …

Aim Neuronal degeneration in the locus coeruleus occurs in the early phase of A lzheimer's
disease, similar to mild cognitive impairment. The locus coeruleus produces norepinephrine …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

The locus coeruleus (LC), the major origin of noradrenergic modulation of the central
nervous system, may play an important role in neuropsychiatric disorders including …